AhR-mediated gene expression in the developing mouse telencephalon.
AhR-mediated gene expression in the developing mouse telencephalon.
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DOI：
10.1016/j.reprotox.2009.05.067
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Portier CJ
中科院分区：
文献类型：
--
作者：
Gohlke JM;Stockton PS;Sieber S;Foley J;Portier CJ
We hypothesize that TCDD induced developmental neurotoxicity is modulated through an AhR dependent interaction with key regulatory neuronal differentiation pathways during telencephalon development. To test this hypothesis we examined global gene expression in both dorsal and ventral telencephalon tissues in E13.5 AhR -/- and wildtype mice exposed to TCDD or vehicle. Consistent with previous biochemical, pathological and behavioral studies, our results suggest TCDD initiated changes in gene expression in the developing telencephalon are primarily AhR dependent, as no statistically significant gene expression changes are evident after TCDD exposure in AhR -/- mice. Based on a gene regulatory network for neuronal specification in the developing telencephalon, the present analysis suggests differentiation of GABAergic neurons in the ventral telencephalon is compromised in TCDD exposed and AhR-/- mice. In addition, our analysis suggests Sox11 may be directly regulated by AhR based on gene expression and comparative genomics analyses. In conclusion, this analysis supports the hypothesis that AhR has a specific role in the normal development of the telencephalon and provides a mechanistic framework for neurodevelopmental toxicity of chemicals that perturb AhR signaling.
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DOI：
10.1093/toxsci/kfn149
发表时间：
2008-11
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Bunger MK;Glover E;Moran SM;Walisser JA;Lahvis GP;Hsu EL;Bradfield CA
通讯作者：
Bradfield CA
影响因子：
10.5
作者：
Bergsland, Maria;Werme, Martin;Muhr, Jonas
通讯作者：
Muhr, Jonas
影响因子：
3.6
作者：
Elferink, CJ;Ge, NL;Levine, A
通讯作者：
Levine, A
影响因子：
3.6
作者：
Huang, GM;Elferink, CJ
通讯作者：
Elferink, CJ
小鼠端脑发育过程中原神经基因调控网络的表征。
影响因子：
5.4
作者：
Gohlke JM;Armant O;Parham FM;Smith MV;Zimmer C;Castro DS;Nguyen L;Parker JS;Gradwohl G;Portier CJ;Guillemot F
通讯作者：
Guillemot F