Kawasaki syndrome and risk factors for coronary artery abnormalities - United States, 1994-2003
Kawasaki syndrome and risk factors for coronary artery abnormalities - United States, 1994-2003
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DOI：
10.1097/01.inf.0000202068.30956.16
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发表时间：
2006-03-01
影响因子：
3.6
通讯作者：
Schonberger, LB
中科院分区：
文献类型：
--
作者：
Belay, ED;Maddox, RA;Schonberger, LB
背景资料：川崎综合征（KS）在美国和其他国家的儿童中造成显着的发病率，并可能导致一系列的心脏和非心脏并发症。方法：描述KS在美国的发生和危险因素的发展冠状动脉异常（CAA），国家KS监测数据进行了分析，KS发病患者在1994-2003年。监测是一个被动的系统，收集的信息是一个标准化的病例报告表。结果：在1994年至2003年期间，3115例符合KS病例定义的患者被报告给国家KS监测系统。KS患者的中位年龄为32个月;男女比例为1.5：1。近三分之一（31.8%）的KS病例发生在1月至3月期间。在研究期间，2798例KS患者中有362例（12.9%）患有CAA。CAA患者的比例从1994年的10.0%上升到2003年的17.8%。年龄小于1岁和9-17岁，男性，亚洲和太平洋岛民种族和西班牙裔（以前未确定的危险因素）显着相关的发展CAA.Conclusions：CAA的增加是由于广泛使用的标准de Zorzi等，导致冠状动脉狭窄的认识增加。导致CAA风险较高的因素，如延迟治疗，特别是在西班牙裔美国人中，需要调查。
Background: Kawasaki syndrome (KS) causes significant morbidity among children in the United States and other countries and can result in a range of cardiac and noncardiac complications.Methods: To describe the occurrence of KS in the United States and risk factors for the development of coronary artery abnormalities (CAA), national KS surveillance data were analyzed for patients with KS onset during 1994-2003. The surveillance is a passive system, and information is collected on a standardized case report form.Results: During 1994 through 2003, 3115 patients who met the KS case definition were reported to the national KS surveillance system. The median age of KS patients was 32 months; the male-female ratio was 1.5:1. Nearly one-third (31.8%) of the cumulative number of KS cases occurred during January through March. During the study period, 362 (12.9%) of 2798 KS patients had CAA. The proportion of patients with CAA increased from 10.0% in 1994 to 17.8% in 2003. Age younger than 1 year and 9-17 years, male sex, Asian and Pacific Islander race and Hispanic ethnicity (a previously unidentified risk factor) were significantly associated with the development of CAA.Conclusions: The increase in CAA was attributed to widespread use of the criteria of de Zorzi et al, resulting in increased recognition of coronary artery dilatations. The factors contributing to a higher risk of CAA, such as delayed treatment, particularly among Hispanics, need to be investigated.