Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.
Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.
复制标题
DOI：
10.1016/j.stem.2008.12.004
复制
发表时间：
2009-01-09
期刊：
影响因子：
23.9
通讯作者：
Kincade PW
中科院分区：
文献类型：
--
作者：
Malhotra S;Kincade PW
There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting that a delicate balance is required between competing Wnt ligands and corresponding signaling pathways to maintain HSC integrity. Some steps in the transitions from HSC to lymphoid progenitor seem to be partially reversible and under the influence of Wnts. In addition, it has been recently suggested that HSC can oscillate between dormant versus active or lineage-biased states. We speculate that Wnts control a reflux process that may sustain stem cell self-renewal and differentiation potential.
登录
查看更多内容
影响因子：
23.9
作者：
Dykstra, Brad;Kent, David;Eaves, Connie
通讯作者：
Eaves, Connie
影响因子：
23.9
作者：
Haug, Jeffrey S.;He, Xi C.;Li, Linheng
通讯作者：
Li, Linheng
影响因子：
64.5
作者：
Adolfsson, J;Månsson, R;Jacobsen, SEW
通讯作者：
Jacobsen, SEW
影响因子：
20.3
作者：
Austin, TW;Solar, GP;Matthews, W
通讯作者：
Matthews, W
影响因子：
64.8
作者：
Chang, Hannah H.;Hemberg, Martin;Huang, Sui
通讯作者：
Huang, Sui