GROWTH PLATE RECONSTRUCTION USING CHONDROCYTE ALLOGRAFT TRANSPLANTS
GROWTH PLATE RECONSTRUCTION USING CHONDROCYTE ALLOGRAFT TRANSPLANTS
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DOI：
10.1097/01241398-198707000-00001
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发表时间：
1987-01-01
影响因子：
1.7
通讯作者：
MANKIN, HJ
中科院分区：
文献类型：
--
作者：
KAWABE, N;EHRLICH, MG;MANKIN, HJ
到目前为止，还没有成功的替代一个完全受损的身体。在同种异体移植板置换的有效性测试中，生长板的软骨细胞被移植到胫骨近端生长板的缺损处。缺损在切除兔骨桥后仍然存在。移植后3周10只兔中有7只和6只兔中有6只恢复了生长并阻止了胫骨畸形的进展。另一方面，死亡的骨骺细胞迅速被骨所取代。目前尚不清楚移植的活细胞是否真的生长或作为一个活的，但惰性的过滤器。
There is, as yet, no successful replacement for a completely damaged physis. In a test of the usefulness of allograft replacement of the plate, growth plate chodnrocytes were transplanted to a defect in the proximal tibial growth plate. The defect remained after resection of a bony bridge that was created in rabbits. Seven of 10 rabbits at 3 weeks and six of 8 rabbits at 6 weeks after transplantation showed resumption of growth and prevented progression of the tibial deformity. Killed epiphyseal cells, on the other hand, were rapidly replaced by bone. It is not clear whether the transplanted live cells actually grew or served as a living, but inert filter.