CD27 is required for generation and long-term maintenance of T cell immunity
CD27 is required for generation and long-term maintenance of T cell immunity
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DOI：
10.1038/80877
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发表时间：
2000-11-01
影响因子：
30.5
通讯作者：
Borst, J
中科院分区：
文献类型：
--
作者：
Hendriks, J;Gravestein, LA;Borst, J
Traf连接的肿瘤坏死因子受体家族成员CD 27被称为T细胞共刺激分子。我们产生了CD 27（-/-）小鼠，发现CD 27对成熟的CD 4（+）和CD 8（+）T细胞功能做出了重要贡献：CD 27支持幼稚T细胞的抗原特异性扩增（但不是效应细胞成熟），独立于CD 28和白细胞介素2的细胞周期促进活性。在CD 27（-/-）小鼠中，对流感病毒的初级CD 4（+）和CD 8（+）T细胞应答受损。删除编码CD 27的基因对T细胞记忆的影响最为深远，反映在延迟的反应动力学和CD 8（+）病毒特异性T细胞数量减少到初次反应中所见的水平。这证明了在T细胞记忆的产生中需要共刺激受体。
The Traf-linked tumor necrosis factor receptor family member CD27 is known as a T cell costimulatory molecule. We generated CD27(-/-) mice and found that CD27 makes essential contributions to mature CD4(+) and CD8(+) T cell function: CD27 supported antigen-specific expansion (but not effector cell maturation) of naive T cells, independent of the cell cycle-promoting activities of CD28 and interleukin 2. Primary CD4(+) and CD8(+) T cell responses to influenza virus were impaired in CD27(-/-) mice. Effects of deleting the gene encoding CD27 were most profound on T cell memory, reflected by delayed response kinetics and reduction of CD8(+) virus-specific T cell numbers to the level seen in the primary response. This demonstrates the requirement for a costimulatory receptor in the generation of T cell memory.