Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
Serologic Evidence of the Geographic Distribution of Bacterial Zoonotic Agents in Kenya, 2007
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DOI：
10.4269/ajtmh.15-0320
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发表时间：
2016-01-01
影响因子：
3.3
通讯作者：
Fields, Barry S.
中科院分区：
文献类型：
--
作者：
Omballa, Victor O.;Musyoka, Raymond N.;Fields, Barry S.
人畜共患疾病加重了发展中国家发热性疾病的负担。我们评估了接触炭疽杆菌、布鲁氏菌、斑点热群立克次体病（SFGR）和斑疹伤寒群立克次体病（TGR），来自2007年在肯尼亚进行的全国性人类免疫缺陷病毒（HIV）血清调查期间收集的15-64岁人群样本。观察到的病原体血清阳性为B。炭疽菌11.3%，布鲁氏菌11.3%。3.0%，SFGR为23.3%，TGR为0.6%。在单变量分析中，每种病原体的血清阳性与以下危险因素显著相关：B。炭疽菌与居住省;布鲁氏菌属。包括性别、教育水平和财富; SFGR包括年龄、教育水平、财富和居住省份; TGR包括居住省份。在多变量分析中，血清阳性与B的财富和省份显著相关。炭疽病与性别、年龄、布氏菌属有关，SFGR与性别、文化程度、居住省份有关，TGR与性别、文化程度、居住省份无关。对这些人畜共患病病原体（尤其是B.炭疽和SFGR）表明存在大量接触。这些病原体应考虑在肯尼亚的发热性疾病的鉴别诊断。
Diseases of zoonotic origin contribute to the burden of febrile illnesses in developing countries. We evaluated serologic evidence of exposure to Bacillus anthracis, Brucella spp., spotted fever group rickettsioses (SFGR), and typhus group rickettsioses (TGR) from samples of persons aged 15-64 years collected during a nationwide human immunodeficiency virus (HIV) serosurvey conducted in 2007 in Kenya. The seropositivity observed for pathogens was B. anthracis 11.3%, Brucella spp. 3.0%, SFGR 23.3%, and TGR 0.6%. On univariate analysis, seropositivity for each pathogen was significantly associated with the following risk factors: B. anthracis with province of residence; Brucella spp. with sex, education level, and wealth; SFGR with age, education level, wealth, and province of residence; and TGR with province of residence. On multivariate analysis, seropositivity remained significantly associated with wealth and province for B. anthracis; with sex and age for Brucella spp; and with sex, education level, and province of residence for SFGR whereas TGR had no significance. High IgG seropositivity to these zoonotic pathogens (especially, B. anthracis and SFGR) suggests substantial exposure. These pathogens should be considered in the differential diagnosis of febrile illness in Kenya.