Bronchodilator reversibility testing in an adult general population;: the importance of smoking and anthropometrical variables on the response to a β2-agonist
Bronchodilator reversibility testing in an adult general population;: the importance of smoking and anthropometrical variables on the response to a β2-agonist
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DOI：
10.1016/j.pupt.2005.07.006
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Gulsvik, A
中科院分区：
文献类型：
--
作者：
Lehmann, S;Bakke, PS;Gulsvik, A
发表的支气管扩张剂可逆性试验的标准截止值忽略了可能影响试验结果的除疾病以外的因素。这项对一般人群的横断面研究的目的是检查沙丁胺醇可逆性试验的反应如何取决于人体测量学变量和吸烟。年龄和性别分层的所有年龄在47 - 48岁和71 - 73岁的成年人的随机样本，居住在卑尔根，挪威被邀请。3506名参加者（69%）在吸入沙丁胺醇400 μ g前后填写问卷并进行肺功能测定，平均（SD）绝对FEV、支气管扩张剂反应、预计%变化和初始%变化在中年人中分别为71（122）ml、2.0老年组分别为64（113）ml、2.4（4.3）%和3.3（5.9）%。在多元线性回归分析，包括调整的初始FEV，在%预测，吸烟和包年呈负相关的所有指数。现在吸烟比过去吸烟更重要。女性、年龄、BMI与百分比变化指数呈正相关，但与BMI的相关性随着身高的增加而降低。排除阻塞性肺疾病或冠心病后，这些趋势没有变化。这项研究表明，吸烟习惯可预测一般人群中中年和老年人沙丁胺醇支气管扩张反应的所有指标。此外，%预测值的变化和%初始指数的变化取决于人体测量变量。然而，尽管吸烟和人体测量变量以及肺功能水平可预测吸入β 2受体激动剂的反应，但这些因素仅解释了测量指标总变异的7 - 16%，因此似乎对测试结果的解释不太重要。(c)2005爱思唯尔有限公司保留所有权利。
Normative cut-off values for the bronchodilator reversibility test are published neglecting factors that may influence the test result other than disease.The objective of this cross-sectional study of a general population was to examine how a salbutamol reversibility test response is depending on anthropometrical variables and smoking.An age and gender stratified random sample of all adults aged 47-48 and 71-73 years living in Bergen, Norway, was invited. The 3506 attendants (69%) filled in a questionnaire and performed spirometry before and after inhalation of 400 mu g salbutamol.The mean (SD) absolute FEV, bronchodilator response, the change in % predicted, and the change in % initial among middle-aged were 71 (122) ml, 2.0 (3.3)%, and 2.4 (4.1)%, and in the elderly 64 (113) ml, 2.4 (4.3)% and 3.3 (5.9)%, respectively. In a multiple linear regression analysis including adjustment for the initial FEV, in % predicted, smoking and pack-years were negatively correlated to all indices. Current smoking was considerably more important than past smoking. Female gender, old age, and BMI were positively correlated with the percentage change indices, but the correlation with BMI decreased with increasing heights. These trends were unchanged after excluding subjects with obstructive lung disease or coronary heart disease.This study demonstrates that smoking habits predict all indices expressing the salbutamol bronchodilator response among middle-aged and elderly from a general population. Also, the change in % predicted and the change in % initial indices are dependent on anthropometrical variables. However, although smoking and anthropometrical variables, as well as level of lung function predict the response to inhaled beta(2)-agonists, these factors explain only 7-16% of the total variation of the measurement indices, and seem therefore of minor importance to the interpretation of the test result. (c) 2005 Elsevier Ltd. All rights reserved.