Steroid production by definitive and fetal zones of the human fetal adrenal gland.
Steroid production by definitive and fetal zones of the human fetal adrenal gland.
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人类胎儿肾上腺的确定区和胎儿区产生类固醇。
DOI：
10.1210/jcem-47-3-603
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. Jaffe
中科院分区：
文献类型：
--
作者：
M. Seron;Christina C. Lawrence;P. Siiteri;R. Jaffe
本研究的目的是评估胎儿肾上腺和胎儿肾上腺对“皮质激素”（皮质醇和其他皮质类固醇）和硫酸脱氢表雄酮（DHAS）产生的相对贡献，以及ACTH和胎儿垂体在这些类固醇分泌中可能的调节作用。在灌注系统中研究了孕10-20周人胎儿肾上腺的离体定形区和胎儿区的类皮质激素和放射免疫测定的DHAS或总芳香化雄激素分泌。不同的功能能力的两个区域，皮质激素被发现主要是由永久区分泌，而DHAS被发现是胎儿区的主要分泌产物。在研究的所有胎龄中，添加ACTH（250 ng/ml）或胎儿垂体匀浆可刺激决定区产生2- 5倍的皮质激素。胎儿区分泌DHAS也受到ACTH的刺激。这些结果表明，在妊娠中期的人胎儿肾上腺的定形区和胎儿区有能力响应ACTH增加皮质激素或DHAS分泌，分别。
This study was performed to assess the relative contributions of the fetal and definitive zones of the human fetal adrenal gland to "corticoid" (cortisol and perhaps other corticosteroids) and dehydroepiandrosterone sulfate (DHAS) production, and the possible regulatory role of ACTH and the fetal pituitary in the secretion of of these steroids. Corticoid and radioimmunoassayable DHAS or total aromatizable androgen secretion by the isolated definitive and fetal zones of the human fetal adrenal gland between 10-20 weeks gestation has been studied in a superfusion system. Different functional capacities of the two zones were seen; corticoids were found to be secreted primarily by the definitive zone, while DHAS was found to be the main secretory product of the fetal zone. Addition of ACTH (250 ng/ml) or fetal pituitary homogenate produced a 2- to 5-fold stimulation of corticoid production by the definitive zone at all gestational ages studied. DHAS secretion by the fetal zone was also stimulated by ACTH. These results indicate that the definitive and fetal zones of the human fetal adrenal gland at midgestation have the capacity to respond to ACTH with increased corticoid or DHAS secretion, respectively.