High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men
High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men
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DOI：
10.1161/circulationaha.104.521344
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发表时间：
2005-08-09
期刊：
影响因子：
37.8
通讯作者：
Griffin, JH
中科院分区：
文献类型：
--
作者：
Deguchi, H;Pecheniuk, NM;Griffin, JH
背景-尽管血脂异常与动脉粥样硬化血栓形成有关，但对静脉血栓形成patients.Methods和Results中的血浆脂蛋白知之甚少-我们使用核磁共振光谱法测定了49例男性静脉血栓形成患者和年龄< 55岁的对照组血液样本中的血浆脂蛋白亚类浓度和载脂蛋白AI和B的抗原水平。静脉血栓形成患者的HDL颗粒、大HDL颗粒、HDL胆固醇和载脂蛋白AI水平显著较低，而LDL颗粒和小LDL颗粒水平显著较高。与对照组相比，患者HDL颗粒和载脂蛋白AI水平降低的四分位数比值比分别为6.5和6.0（95%CI，2.3 - 19和2.1 - 17）。载脂蛋白B/载脂蛋白AI比值和LDL胆固醇/HDL胆固醇比值的比值比分别为6.3和2.7（95% CI，1.9 - 21和1.1 - 6.5）。当分析肝脂酶、内皮脂酶和胆固醇酯转移蛋白基因的多态性时，胆固醇酯转移蛋白TaqI B1/B2多态性的等位基因频率与对照组有显著差异，与观察到的低密度脂蛋白和高密度脂蛋白的模式相一致。55岁的患者与血脂异常相关，包括HDL颗粒水平降低、小LDL颗粒水平升高和载脂蛋白B/载脂蛋白AI比值升高。这种异常脂蛋白血症似乎与胆固醇酯转运蛋白基因型差异有关。
Background - Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients.Methods and Results - We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged < 55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 ( 95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 ( 95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL.Conclusions - Venous thrombosis in men aged < 55 years old is associated with dyslipoproteinemia involving lower levels of HDL particles, elevated levels of small LDL particles, and an elevated ratio of apolipoprotein B/apolipoprotein AI. This dyslipoproteinemia seems associated with a related cholesteryl ester transfer protein genotype difference.