Ovariectomy leads to a rapid increase in rat placental lactogen secretion.
Ovariectomy leads to a rapid increase in rat placental lactogen secretion.
复制标题
卵巢切除术导致大鼠胎盘催乳素分泌迅速增加。
作者：
May C. Robertson;Robert E. Owens;John Klindt;H. G. Friesen
用放射免疫分析法测定了孕晚期大鼠经多次内分泌切除后血清胎盘催乳素（rPL）水平。肾上腺切除术或单侧卵巢切除术对血清rPL水平无显著影响。孕中期对母鼠进行垂体切除导致孕晚期血清rPL显著增加。孕14天或孕16天的大鼠双侧卵巢切除导致血清rPL水平迅速升高2天，随后随着胎儿被重吸收或流产而逐渐降低。肾上腺切除术联合卵巢切除术导致血清rPL水平持续升高，高于单纯双侧卵巢切除术。当孕激素（4毫克/大鼠X天）和雌酮（500纳克/大鼠X天）或17 β-雌二醇（100或200纳克/大鼠X天）给予卵巢切除妊娠大鼠，血清rPL保持升高和保留的概念。总之，我们的研究表明，卵巢和肾上腺因素影响rPL分泌。
Serum placental lactogen (rPL) levels were measured by RIA in late pregnant rats subjected to a number of endocrine ablations. Adrenalectomy or unilateral ovariectomy had no significant effect on serum rPL levels. Hypophysectomy of the dam at midpregnancy resulted in a significant increase in serum rPL at late pregnancy. Bilateral ovariectomy of day-14 or -16 pregnant rats led to a rapid increase in serum rPL levels for 2 days followed by a gradual decrease as fetuses were reabsorbed or aborted. Adrenalectomy combined with ovariectomy led to sustained, elevated levels of serum rPL which were greater than those seen with bilateral ovariectomy alone. When progesterone (4 mg/rat X day) and estrone (500 ng/rat X day) or 17 beta-estradiol (100 or 200 ng/rat X day) were administered to ovariectomized pregnant rats, serum rPL remained elevated and the conceptuses were retained. In conclusion our studies have shown that ovarian and adrenal factors influence rPL secretion.