Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development.
Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development.
复制标题
DOI：
10.1016/s0169-409x(03)00052-8
复制
发表时间：
2003-06
影响因子：
16.1
通讯作者：
Sang-Hyun Lee;M. Hannink
中科院分区：
文献类型：
--
作者：
Sang-Hyun Lee;M. Hannink
真核生物细胞独特的细胞核和细胞质区室要求发生在细胞核中的代谢过程，如基因转录，与发生在细胞质中的相关过程协调。许多转录因子的稳态核丰度是核输入和核输出之间动态平衡的净结果。控制转录因子核质分布的核输入和核输出机制在多个水平上受到调节，包括改变顺式作用转运信号的可及性的翻译后修饰、结合和从隔室特异性锚的释放以及特异性转运因子或特异性核孔蛋白的选择性利用。转录因子的净核丰度代表多个信号转导途径的积分总和。调节转录因子核质转运的机制可能为药物开发提供新的机会。
The distinctive nuclear and cytoplasmic compartments of a eukaryote cell requires that metabolic processes which occur in the nucleus, such as gene transcription, are coordinated with related processes which occur in the cytoplasm. The steady state nuclear abundance of many transcription factors is the net outcome of a dynamic balance between nuclear import and nuclear export. Nuclear import and nuclear export mechanisms that govern the nucleocytoplasmic distribution of transcription factors are regulated at multiple levels, including post-translational modifications that alter the accessibility of cis-acting transport signals, binding and release from compartment-specific anchors, and the selective utilization of specific transport factors or specific nucleoporins. The net nuclear abundance of a transcription factor represents the integrated sum of multiple signal transduction pathways. Mechanisms that regulate nucleocytoplasmic transport of transcription factors may provide novel opportunities for drug development.