Interleukin-8 in chronic renal failure and dialysis patients.
Interleukin-8 in chronic renal failure and dialysis patients.
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慢性肾功能衰竭和透析患者中的白介素 8。
DOI：
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发表时间：
1994
影响因子：
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通讯作者：
Y. Tsubakihara
中科院分区：
文献类型：
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作者：
I. Nakanishi;A. Moutabarrik;N. Okada;E. Kitamura;A. Hayashi;Tetsuo Syouji;M. Namiki;M. Ishibashi;D. Zaid;Y. Tsubakihara
本研究共纳入105例患者，其中慢性肾小球肾炎伴肾功能正常（CGN患者）10例，尿毒症患者（CRF患者）36例，持续动态腹膜透析患者（CAPD）无腹膜炎19例，CAPD伴腹膜炎3例，慢性血液透析（HD） 37例，分为短期HD、15例；中期HD 12例；长期HD患者10例。采用特异性免疫分析法检测IL-8和另外两种促炎细胞因子IL-6和TNF α。慢性肾功能衰竭患者血清IL-8、IL-6、TNF - α水平较正常人显著升高（P < 0.0001, P < 0.05, P < 0.0001）。CAPD患者血清IL-8、IL-6和TNF α水平升高最为显著（P < 0.0001）。无腹膜炎的CAPD患者在腹膜透析液（PDE）中IL-8或IL-6水平相对较低，而在几乎所有被检测的患者中均未检测到PDE- tnf α。腹膜炎患者血清和PDE中IL-8、IL-6和TNF - α水平均较高。腹膜炎临床恢复的特点是血清和透析液中IL-8、IL-6和TNF - α迅速下降。HD患者血清IL-8、IL-6、TNF - α水平均明显高于正常人（P < 0.05、P < 0.05、P < 0.01）。（摘要删节250字）
A total of 105 patients participated in this study, including 10 with chronic glomerulonephritis with normal renal function (CGN patients), 36 uraemic patients (CRF patients), 19 continuous ambulatory peritoneal dialysis patients (CAPD) without peritonitis, three CAPD patients with peritonitis, 37 patients undergoing chronic haemodialysis (HD) divided into short-term HD, 15 patients; medium-term HD, 12 patients; and long-term HD, 10 patients. IL-8 and two other proinflammatory cytokines, IL-6 and TNF alpha were tested using a specific immunoassay. IL-8, IL-6, and TNF alpha serum levels were significantly increased in patients with chronic renal failure compared to their levels in normal individuals (P < 0.0001, P < 0.05 and P < 0.0001 respectively). The most pronounced increment in IL-8, IL-6 and TNF alpha serum levels was observed in CAPD patients (P < 0.0001). CAPD patients without peritonitis showed relatively low levels of IL-8 or IL-6 in peritoneal dialysate effluents (PDE), whereas PDE-TNF alpha were not detectable in almost all patients tested. Patients with peritonitis showed very high serum and PDE levels of IL-8, IL-6 and TNF alpha. The clinical recovery from peritonitis was characterized by a rapid fall in IL-8, IL-6 and TNF alpha in serum and dialysate. HD patients showed a significant increase in serum levels of IL-8 and also IL-6 and TNF alpha compared to normal individuals (P < 0.05, P < 0.05 and P < 0.01 respectively).(ABSTRACT TRUNCATED AT 250 WORDS)