Patterns of differentiation in various sympathetic efferents induced by changes of blood gas composition and by central thermal stimulation in anesthetized rabbits.
Patterns of differentiation in various sympathetic efferents induced by changes of blood gas composition and by central thermal stimulation in anesthetized rabbits.
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麻醉兔血气成分变化和中枢热刺激诱导的各种交感传出细胞的分化模式。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
E. Simon
中科院分区：
文献类型：
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作者：
M. Iriki;W. Riedel;E. Simon
在麻醉、制动和人工通气的家兔中同时记录心脏和肠交感传出神经的放电、耳皮肤温度、动脉压和心率。观察不同程度的低氧、高碳酸血症、窒息和热刺激脊髓的反应。心脏交感神经活动和间接确定的皮肤交感神经活动减少，在中度至重度缺氧和高碳酸血症，而内脏活动增加。在极度缺氧或窒息状态下（PaO 2低于20-25 mm Hg），心脏和肠道交感神经活动普遍增加。在脊髓冷却引起皮肤血管收缩，而心脏和肠交感神经活动减少。在脊髓加热过程中，反向反应，即。例如，引起皮肤中血管收缩张力的降低以及心脏和肠交感神经活性的增加。双侧迷走神经切断并不改变在血气成分变化和中枢热刺激时观察到的交感传出神经的区域分化模式。在非迷走神经切断和迷走神经切断动物的心率反应的比较表明，迷走神经和交感神经传出有助于在本调查中观察到的心率反应。
Summary The discharges of cardiac and intestinal sympathetic efferent, ear skin temperature, arterial pressure, and heart rate were simultaneously recorded in anesthetized, immobilized, and artificially ventilated rabbits. The responses to hypoxia and hypercapnia of various degrees, to asphyxia, and to thermal stimulation of the spinal cord were observed. Cardiac sympathetic activity and as indirectly determined cutaneous sympathetic activity were reduced during moderate to severe hypoxia and during hypercapnia, whereas splanchnic activity increased. In states of extreme hypoxia or asphyxia (PaO2 below 20-25 mm Hg) there was a generalized increase of cardiac and intestinal sympathetic activity. During spinal cord cooling cutaneous vasoconstriction was evoked, while cardiac and intestinal sympathetic activity decreased. During spinal cord heating the reverse response, i. e., reduction of vasoconstrictor tone in the skin and increase of cardiac and intestinal sympathetic activity, was elicited. Bilateral vagus transection did not change the patterns of regional differentiation of sympathetic efferents observed during changes of blood gas composition and central thermal stimulation. Comparison of the heart rate responses in non-vagotomized and vagotomized animals revealed that both vagal and sympathetic efferents contributed to the heart rate responses observed in the present investigation.