Hepatocyte growth factor protects against Fas‐mediated liver apoptosis in transgenic mice
Hepatocyte growth factor protects against Fas‐mediated liver apoptosis in transgenic mice
复制标题
DOI：
10.1111/j.1478-3231.2009.02102.x
复制
发表时间：
2009-11
影响因子：
6.7
通讯作者：
Hideyuki Suzuki;M. Toyoda;N. Horiguchi;S. Kakizaki;Tatsuya Ohyama;D. Takizawa;T. Ichikawa;Ken Sato;H. Takagi;M. Mori
中科院分区：
文献类型：
--
作者：
Hideyuki Suzuki;M. Toyoda;N. Horiguchi;S. Kakizaki;Tatsuya Ohyama;D. Takizawa;T. Ichikawa;Ken Sato;H. Takagi;M. Mori
背景：细胞凋亡通过Fas/Fas配体信号系统在多种肝病的发生发展中起着重要作用。给小鼠注射激动型抗Fas抗体会导致大量的肝细胞凋亡和暴发性肝衰竭。包括肝细胞生长因子(HGF)在内的几种生长因子已被发现可防止细胞凋亡。
Background: Apoptosis via the Fas/Fas ligand signalling system plays an important role in the development of various liver diseases. The administration of an agonistic anti‐Fas antibody to mice causes massive hepatic apoptosis and fulminant hepatic failure. Several growth factors including hepatocyte growth factor (HGF) have been found to prevent apoptosis.