Early hematopoietic and vascular development in the chick
Early hematopoietic and vascular development in the chick
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DOI：
10.1387/ijdb.170291gs
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发表时间：
2018-01-01
影响因子：
0.7
通讯作者：
Sheng, Guojun
中科院分区：
文献类型：
--
作者：
Nagai, Hiroki;Shin, Masahiro;Sheng, Guojun
造血和血管发育研究领域的起源应归功于鸡胚胎。在这个模式生物中，首次提出了造血干细胞、血管母细胞和血源性内皮等许多关键概念。在过去的二十年里，基因上易驯化的模特逐渐取代了小鸡。然而，比较基因组学、转录组学和启动子组学的进展预示着鸡胚胎将重新成为造血/血管研究的强大模型。本文综述了鸡早期血液/血管发育的研究现状，主要集中在胚胎外和侧板中胚层区域的原始造血和早期血管网络的形成过程。重点是血液和内皮细胞之间的本体论和分子联系，以及作为血液和内皮细胞共同前体的成纤维细胞与体腔上皮衬里细胞之间的进化关系。还讨论了早期血液/血管发育和后来最终的造血之间的联系。最后，强调了鸡模型在血液/血管系统的比较和组学水平研究中的潜在应用。
The field of hematopoietic and vascular developmental research owes its origin to the chick embryo. Many key concepts, such as the hematopoietic stem cell, hemangioblast and hemogenic endothelium, were first proposed in this model organism. Genetically tractable models have gradually replaced the chick in the past two decades. However, advances in comparative genomics, transcriptomics and promoteromics promise a re-emergence of the chick embryo as a powerful model for hematopoietic/vascular research. This review summarizes the current status of our understanding of early blood/vascular development in the chick, focusing primarily on the processes of primitive hematopoiesis and early vascular network formation in the extraembryonic and lateral plate mesoderm territories. Emphasis is given to ontological and molecular association between the blood and endothelial cells and to the evolutionary relationship between the heman-gioblasts, common precursors for the blood and endothelial lineages, and the coelomic epithelial lining cells. Links between early blood/vascular development and later definitive hematopoiesis are also discussed. Finally, potential applications of the chick model for comparative and omics-level studies of the blood/vascular system are highlighted.