Rapid visual stimulation induces N-methyl-D-aspartate receptor-dependent sensory long-term potentiation in the rat cortex
Rapid visual stimulation induces N-methyl-D-aspartate receptor-dependent sensory long-term potentiation in the rat cortex
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DOI：
10.1097/01.wnr.0000209004.63352.10
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发表时间：
2006-04-03
期刊：
影响因子：
1.7
通讯作者：
Abraham, WC
中科院分区：
文献类型：
--
作者：
Clapp, WC;Eckert, MJ;Abraham, WC
此前，我们已经证明，快速呈现的感觉刺激(视觉或听觉)可以诱导从人类大脑皮层记录的感觉诱发电位的长期增加。长时程增强被认为是这些增加的潜在机制。在本实验中，我们将相同的视觉范式应用于麻醉大鼠，以探讨这种效应的性质和机制。我们的结果表明，视觉诱发反应在至少1h内显著增强，当被跟踪时，直到出现光性破伤风后5h，而且这种增强是N-甲基-(D)-天冬氨酸受体依赖的，并且是皮质产生的。这种类型的感觉长时程增强可能是知觉学习的基础，并作为研究感觉诱发可塑性的模型系统。《神经报告》17：511-515(C)2006 Lippincott Williams&Wilkins.
Previously we have demonstrated that rapidly presented sensory stimulation (visual or auditory) can induce long-lasting increases in sensory evoked potentials recorded from the human cortex. Long-term potentiation was suggested as the underlying mechanism of these increases. In the present experiment, we applied the same visual paradigm to anesthetized rats to investigate the properties and mechanisms of this effect. Our results indicated that visual evoked responses were significantly enhanced for at least I h and, when followed, up to 5 h after the presentation of a 'photic tetanus' Furthermore, the potentiation was N-methyl-(D)-aspartate receptor-dependent and cortically generated. This type of sensory long-term potentiation may underlie perceptual learning, and serves as a model system for investigating sensory-evoked plasticity. NeuroReport 17:511-515 (c) 2006 Lippincott Williams & Wilkins.