Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables.
Plasma concentrations of cholesteryl ester transfer protein in hyperlipoproteinemia. Relation to cholesteryl ester transfer protein activity and other lipoprotein variables.
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高脂蛋白血症中胆固醇酯转移蛋白的血浆浓度。
DOI：
10.1161/01.atv.11.4.797
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Marcel,YL
中科院分区：
文献类型：
--
作者：
McPherson,R;Mann,CJ;Tall,AR;Hogue,M;Martin,L;Milne,RW;Marcel,YL
胆固醇酯转运蛋白（CETP）是胆固醇逆向转运的重要途径。通过放射免疫测定法测量两组不同高脂蛋白血症受试者空腹血浆中CETP的浓度。放射免疫法测定的CETP浓度与正常人血浆胆固醇酯转运活性密切相关（r = 0.86）。在第一组58例患者中，与79例正常受试者以及高胆固醇血症（+26%）和合并高脂蛋白血症（+25%）受试者相比，血浆CETP浓度显著升高，但在中度高胆固醇血症受试者中没有改变。异常β脂蛋白血症（+68%）和重度乳糜微粒血症（+85%）患者的血浆CETP水平明显升高。在第二组50例高脂蛋白血症受试者中获得了类似的结果。血浆CETP水平与总胆固醇（r = 0.52）、极低密度脂蛋白（VLDL）胆固醇（r = 0.63）和载脂蛋白E（r = 0.40）呈显著相关。通过饮食方式纠正脂蛋白表型导致乳糜微粒血症和异常β脂蛋白血症患者血浆CETP浓度显著降低。在这些受试者中，血浆高密度脂蛋白胆固醇浓度随着CETP降低而升高。这些研究表明CETP水平的增加与通过低密度脂蛋白、β-VLDL或乳糜微粒残留物增强的外周胆固醇转运相关。
Cholesteryl ester transfer protein (CETP) mediates an important pathway for reverse cholesterol transport. Concentrations of CETP in fasting plasma were measured by radioimmunoassay in two different groups of hyperlipoproteinemic subjects. Plasma CETP concentrations measured by radioimmunoassay correlated closely with cholesterol ester transfer activity in normal plasma (r = 0.86). In the first group of 58 patients, plasma CETP concentrations were significantly increased, as compared with those in 79 normal subjects and in hypercholesterolemic (+26%) and combined hyperlipoproteinemic (+25%) subjects but were not altered in moderately hypertriglyceridemic subjects. Marked elevations in plasma CETP levels were documented in patients with dysbetalipoproteinemia (+68%) and severe chylomicronemia (+85%). Similar results were obtained in a second population of 50 hyperlipoproteinemic subjects. Significant correlations were found between plasma CETP levels and total cholesterol (r = 0.52), very low density lipoprotein (VLDL) cholesterol (r = 0.63), and apolipoprotein E concentration (r = 0.40). Correction of the lipoprotein phenotype by dietary means resulted in significant reductions in plasma CETP concentrations in patients with chylomicronemia and dysbetalipoproteinemia. In these subjects, plasma high density lipoprotein cholesterol concentrations increased as CETP decreased. These studies indicate that CETP levels increase in association with enhanced peripheral cholesterol transport via low density lipoprotein, beta-VLDL, or chylomicron remnants.
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DOI：
--
发表时间：
1983
期刊：
Arteriosclerosis
影响因子：
--
作者：
R. Milne;R. Theolis;R. Verdery;Y. Marcel
通讯作者：
Y. Marcel
由血浆蛋白因子控制的人高密度脂蛋白和富含甘油三酯的脂蛋白之间胆固醇酯的转移。
影响因子：
5.3
作者：
Y. Marcel;C. Vezina;Babie Teng;A. Sniderman
通讯作者：
A. Sniderman
由血浆蛋白因子介导的人血浆高密度脂蛋白和低密度脂蛋白之间的胆固醇酯交换。
影响因子：
5.3
作者：
A. Sniderman;B. Teng;C. Vezina;Y. Marcel
通讯作者：
Y. Marcel
胆固醇酯转移蛋白介导的 Hep G2 细胞摄取高密度脂蛋白胆固醇酯的机制。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Rinninger,F;Pittman,RC
通讯作者：
Pittman,RC
致动脉粥样硬化饮食会增加兔肝脏中胆固醇酯转移蛋白信使 RNA 的水平。
DOI：
10.1172/jci114446
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Quinet,EM;Agellon,LB;Kroon,PA;Marcel,YL;Lee,YC;Whitlock,ME;Tall,AR
通讯作者：
Tall,AR