Specialty Supplements and Prostate Cancer Risk in the VITamins And Lifestyle (VITAL) Cohort
Specialty Supplements and Prostate Cancer Risk in the VITamins And Lifestyle (VITAL) Cohort
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DOI：
10.1080/01635581.2011.553022
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
White, Emily
中科院分区：
文献类型：
--
作者：
Brasky, Theodore M.;Kristal, Alan R.;White, Emily
虽然有证据表明，从前列腺癌细胞系和啮齿动物模型的研究，几种补充剂可能有维生素，抗氧化剂，或其他抗癌特性，很少有流行病学研究已经检查了非维生素，非矿物质，osspecialtyo补充剂的使用和前列腺癌风险之间的关联。参与者，50-76岁，35，239名VITAL和生活方式（VITAL）队列的男性成员，他们是华盛顿州西部的居民，并在2000-2002年完成了广泛的基线问卷调查。参与者回答了他们使用专业补充剂的频率（天/周）和持续时间（年）。从监测、流行病学和最终结果登记处获得了1，602例侵袭性前列腺癌。通过考克斯比例风险模型估计多变量校正的风险比（HR）和95%置信区间（95% CI）。任何使用graplitazone补充剂与41%（HR 0.59，95%CI：0.40-0.86）的总前列腺癌风险降低相关。使用软骨素、辅酶Q10、鱼油、大蒜、银杏叶、人参、氨基葡萄糖或锯棕榈没有关联。石墨可能是一种潜在的化学预防剂;然而，由于目前的证据有限，它还不应该被推广用于预防前列腺癌。
Although there is evidence from studies of prostate cancer cell lines and rodent models that several supplements may have antiinflammatory, antioxidant, or other anticancer properties, few epidemiologic studies have examined the association between nonvitamin, nonmineral, ospecialtyo supplement use and prostate cancer risk. Participants, 50-76 yr, were 35,239 male members of the VITamins and Lifestyle (VITAL) cohort who were residents of western Washington state, and who completed an extensive baseline questionnaire in 2000-2002. Participants responded about their frequency (days/wk) and duration (yr) of specialty supplement uses. 1,602 incident invasive prostate cancers were obtained from the Surveillance, Epidemiology, and End Results registry. Multivariate-adjusted hazards ratios (HR) and 95% confidence intervals (95% CI) were estimated by Cox proportional hazards models. Any use of grapeseed supplements was associated with a 41% (HR 0.59, 95% CI: 0.40-0.86) reduced risk of total prostate cancer. There were no associations for use of chondroitin, coenzyme Q10, fish oil, garlic, ginkgo biloba, ginseng, glucosamine, or saw palmetto. Grapeseed may be a potential chemopreventive agent; however, as current evidence is limited, it should not yet be promoted for prevention of prostate cancer.