The Case of the Disappearing Spindle Burst.
The Case of the Disappearing Spindle Burst.
复制标题
消失的主轴爆裂事件。
DOI：
10.1155/2016/8037321
复制
发表时间：
2016
影响因子：
3.1
通讯作者：
Blumberg,MarkS
中科院分区：
文献类型：
--
作者：
Tiriac,Alexandre;Blumberg,MarkS
睡眠纺锤波是10-15 Hz的短暂皮层振荡，主要发生在成年哺乳动物的非REM（安静）睡眠期间，被认为有助于学习和记忆。纺锤波爆发在现象学上类似于睡眠纺锤波，但它们主要发生在婴儿早期，并由外周感觉活动触发（例如，视网膜波）;因此，纺锤波爆发被认为可以组织发育中大脑的神经网络，并与感觉外周建立功能联系。而自发的视网膜波触发的纺锤波爆发的视觉皮层是一个短暂的功能，早期发展，肌阵挛抽搐驱动纺锤波爆发的感觉运动皮层持续到成年。此外，抽搐和与之相关的纺锤波爆发只发生在REM（主动）睡眠期间。奇怪的是，尽管抽搐持续到成年，但在成人感觉运动皮层中尚未报道抽搐相关的纺锤体爆发。这就提出了一个问题，即这种纺锤体爆发活动是否不会发生在成年期，或者，发生，但尚未被发现。如果抽搐相关的纺锤波爆发确实发生在成年人身上，它们可能有助于感觉运动系统的校准、维护和修复。
Sleep spindles are brief cortical oscillations at 10–15 Hz that occur predominantly during non‐REM (quiet) sleep in adult mammals and are thought to contribute to learning and memory. Spindle bursts are phenomenologically similar to sleep spindles, but they occur predominantly in early infancy and are triggered by peripheral sensory activity (e.g., by retinal waves); accordingly, spindle bursts are thought to organize neural networks in the developing brain and establish functional links with the sensory periphery. Whereas the spontaneous retinal waves that trigger spindle bursts in visual cortex are a transient feature of early development, the myoclonic twitches that drive spindle bursts in sensorimotor cortex persist into adulthood. Moreover, twitches—and their associated spindle bursts—occur exclusively during REM (active) sleep. Curiously, despite the persistence of twitching into adulthood, twitch‐related spindle bursts have not been reported in adult sensorimotor cortex. This raises the question of whether such spindle burst activity does not occur in adulthood or, alternatively, occurs but has yet to be discovered. If twitch‐related spindle bursts do occur in adults, they could contribute to the calibration, maintenance, and repair of sensorimotor systems.