An efficient and chemoselective iron catalyst for the hydrogenation of ketones
An efficient and chemoselective iron catalyst for the hydrogenation of ketones
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DOI：
10.1021/ja071159f
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发表时间：
2007-05-09
影响因子：
15
通讯作者：
Guan, Hairong
中科院分区：
文献类型：
--
作者：
Casey, Charles P.;Guan, Hairong
铁配合物1含有电子耦合的酸性和非酸性氢，在温和条件下催化酮的氢化。该氢化催化剂显示出对醛、酮和亚胺的高化学选择性，并且分离的CC、CC、C-X、-NO2、环氧化物和酯官能团不受氢化条件的影响。机理研究已经建立了一个可逆的氢转移步骤，然后快速二氢活化。相同的铁络合物也催化酮的转移氢化。
Iron complex 1 containing electronically coupled acidic and hydridic hydrogens catalyzes the hydrogenation of ketones under mild conditions. This hydrogenation catalyst shows high chemoselectivity for aldehydes, ketones, and imines, and isolated CC, CC, C-X, -NO2, epoxides, and ester functions are unaffected by the hydrogenation conditions. Mechanistic studies have established a reversible hydrogen transfer step followed by rapid dihydrogen activation. The same iron complex also catalyzes transfer hydrogenation of ketones.