Making of a Schwann
Making of a Schwann
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DOI：
10.1016/0168-9525(96)81411-9
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发表时间：
1996-03-01
影响因子：
11.4
通讯作者：
Gruss, P
中科院分区：
文献类型：
--
作者：
Kioussi, C;Gruss, P
当原腹背侧中胚层诱导上覆的外胚层形成神经板时，脊椎动物神经系统的起源就开始了。该板折叠形成神经管和神经嵴细胞（NCC；胚胎干细胞的迁移群体，在上午产生）。多能NCC穿透球膜，在迁移至体内适当部位的过程中增殖，并最终分化为神经细胞和神经胶质细胞类型。如果NCC从密切相关的轴突中接收到适当的分子线索，它们最终会分化为髓鞘雪旺细胞(mSC)。这些刺激被转导至雪旺细胞(SC)细胞核，并导致许多可能改变SC表型的基因的差异表达。迄今为止，三种转录因子与 mSC 表型的建立有关：PAX3，一种含有配对结构域的蛋白质； KROX20，一种锌指蛋白； SCIP，一种 POU 同源域蛋白。
The genesis of vertebrate nervous systems begins when the dorsal mesoderm of the gastmla induces the overlying ectoderm to form the neural plate. The plate folds to become the neuial tube and the neural crest cells (NCCs; a migratory population of embryonic stem cells, which are generated at the am). Pluripotent NCCs penetrate the ba~ l lamina, proliferate during migration to appropriate sites in the body, and terminally differentiate into neural and glial cell types. NCCs ultimately differentiate into myelin Schwann cells (mSCs) if they receive the appropriate molecular cue from closely associated axons.These stimuli are transduced to the Schwann cell (SC) nucleus and result in the differential expression of a number of genes that might alter the SC phenotype. To date, three transcription factors have been implicated in the establishment of the mSC phenotype: PAX3, a paired-domaincontaining protein; KROX20, a zincfinger protein; and SCIP, a POU homeodomain protein.