Behavioral profile of CCK2 receptor-deficient mice
Behavioral profile of CCK2 receptor-deficient mice
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DOI：
10.1016/s0893-133x(01)00291-3
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发表时间：
2001-11-01
影响因子：
7.6
通讯作者：
Roques, BP
中科院分区：
文献类型：
--
作者：
Daugé, V;Sebret, A;Roques, BP
CCK 2受体缺陷小鼠用于研究该受体在体内行为中的作用。突变小鼠在牵引和旋转试验中表现出神经肌肉损伤，但在烟囱试验中没有。脑胆囊收缩素已被证明参与应激相关行为。然而，CCK 2受体缺陷型小鼠在高架十字迷宫和运动条件抑制试验中与野生型小鼠相比没有表现出行为改变，表明CCK 2受体失效后很可能发生代偿机制。另一方面，在活动计中观察到过度运动活动，这可能与环境习惯性损伤有关。最后，正如CCK 2激动剂引起的相反作用所预期的那样，CCK 2受体缺陷小鼠在自发交替行为中表现出受损，这支持了CCK 2受体在注意力和/或记忆过程中的生理作用。这一结果被CCK 2拮抗剂给药后在这些功能中观察到的缺陷所加强。(C)2001年美国神经精神药理学学会。出版社：Elsevier Science Inc.
CCK2 receptor-deficient mice were used to investigate in vivo the role of this receptor in behavior. Mutant mice showed a neuromuscular impairment in the traction and rotarod tests but not in the chimney test. Brain cholecystokinin has been shown to participate in stress-related behaviors. However, CCK2 receptor-deficient mice did not show behavioral modifications compared to wild-type mice in the elevated plus maze and in the motility conditioned suppression test, indicating that compensatory mechanisms very likely occur following CCK2 receptor invalidation. On the other hand, a hyperlocomotor activity was observed in actimeter which can be related to an impairment in environmental habituation. Finally, CCK2 receptor-deficient mice showed an impairment of performance in the spontaneous alternation behavior as expected from the opposite effects evoked by CCK2 agonists, supporting the physiological role of CCK2 receptors in attention and/or memory processes. This result is reinforced by the defects observed in these functions after the administration of CCK2 antagonists. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.