Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children.
Comparison of the 13C-urea blood test to histology and rapid urease testing in the diagnosis of Helicobacter pylori infection in children.
复制标题
13C-尿素血液检测与组织学和快速尿素酶检测在儿童幽门螺杆菌感染诊断中的比较。
DOI：
10.1097/01.mpg.0000243426.78721.bc
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发表时间：
2007
影响因子：
2.9
通讯作者：
Wagner,DavidA
中科院分区：
文献类型：
--
作者：
Jolley,ChristopherD;Wagner,DavidA
目的：幽门螺杆菌感染常见于腹痛患儿。组织学是诊断感染的权威手段，需要内窥镜检查和镇静，这使得它具有侵入性，而且成本高昂。我们的目的是比较组织学和一种侵入性更小、更安全的方法-13C-尿素血液试验。患者和方法：40名接受上内窥镜检查的腹痛儿童被随机分成两种剂量的13C-尿素。取几个活组织作组织学和快速尿素酶检测。结果：无论13C-尿素的剂量是多少，与组织学或快速尿素试验相比，13C-尿素血液检测的准确率都很高(89%)。血检的灵敏度和特异度分别为83%和91%。小剂量13C-尿素血检与组织学检测准确率为100%。结论：13C-尿素血检对儿童幽门螺杆菌感染的诊断与组织学检查具有可比性，小剂量13C-尿素对血检结果无不良影响。儿童对13C-尿素血试验的耐受性良好。
Objective:Helicobacter pylori infection is commonly investigated in children with abdominal pain. The definitive means of diagnosing infection, histology, requires endoscopy and sedation, making it invasive and expensive. Our objective was to compare histology against a less invasive and safer method, the 13 C-urea blood test.Patients and Methods:Forty children with abdominal pain undergoing upper endoscopy were randomized into either of 2 dosages of 13 C-urea. Several biopsies were taken for histology and rapid urease testing. After endoscopy, each child ingested a randomly assigned dosage of either 75 mg or 125 mg 13 C-urea, and blood was withdrawn 30 min later.Results:Irrespective of the dosage of 13 C-urea, the 13 C-urea blood test performed with high accuracy (89%) when compared against either histology or rapid urease testing. The sensitivity and specificity of the blood test was 83% and 91%, respectively. When the smaller dosage of 13 C-urea was used, the accuracy of the blood test was 100% compared with histology. There were no adverse events related to using either dosage of 13 C-urea.Conclusions:The 13 C-urea blood test may be comparable with histology in diagnosing H pylori infection in children, and the smaller dosage of 13 C-urea does not adversely affect blood test performance. The 13 C-urea blood test is well tolerated in children.