Streptococcal DNase B Is Immunologically Identical to Superantigen SpeF but Involves Separate Domains
Streptococcal DNase B Is Immunologically Identical to Superantigen SpeF but Involves Separate Domains
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链球菌 DNase B 在免疫学上与超抗原 SpeF 相同，但涉及不同的结构域
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
M. Norgren
中科院分区：
文献类型：
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作者：
A. Eriksson;Björn Eriksson;S. Holm;M. Norgren
先前关于链球菌超抗原SpeF可能与dna酶B相同的观点在本研究中得到了证实。多克隆SpeF特异性抗血清能够抑制DNA酶b对甲基绿DNA的解聚。然而，t细胞的有丝分裂性和核酸酶活性似乎涉及SpeF上单独的免疫表位，因为具有中和SpeF有丝分裂活性的血清并不总是抑制DNA酶活性。
ABSTRACT The previous suggestion that streptococcal superantigen SpeF might be identical to DNase B was confirmed in this study. Polyclonal SpeF-specific antisera were able to inhibit depolymerization of methyl-green DNA by DNase B. However, T-cell mitogenicity and nuclease activity appear to involve separate immune epitopes on SpeF, since sera with the capacity to neutralize the mitogenic activity of SpeF did not always inhibit the DNase activity.
DOI：
10.1073/pnas.90.16.7676
发表时间：
1993-08-15
影响因子：
11.1
作者：
KAPUR, V;MAJESKY, MW;MUSSER, JM
通讯作者：
MUSSER, JM