Comparing cognitive functioning in schizophrenia and autism using WAIS-III
Comparing cognitive functioning in schizophrenia and autism using WAIS-III
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DOI：
10.1016/j.rasd.2014.03.001
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发表时间：
2014-07-01
影响因子：
2.5
通讯作者：
Lobbestael, Jill
中科院分区：
文献类型：
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作者：
de Boer, Marion;Spek, Annelies A.;Lobbestael, Jill
本研究的主要目的是调查精神分裂症和自闭症成人之间一般认知功能的差异和相似之处，因为这还没有得到系统的研究。我们采用横断面设计比较成年精神分裂症（n = 27），自闭症（n = 114）和健康对照组（n = 30）。精神分裂症的诊断基于DSM-IV轴I（SCID-I）的结构化临床访谈，行为症状用阳性和阴性症状量表（PANSS）评估。自闭症的诊断采用DSM-IV自闭症谱系障碍问卷和自闭症诊断访谈（修订版）。韦氏成人智力量表第三版（WAIS-III）用于评估认知功能。所有参与者年龄在18至65岁之间，最低全量表智力为80。结果显示，精神分裂症患者的加工速度显著低于孤独症患者和健康对照组。在精神分裂症患者中，发现处理速度障碍和阴性症状之间存在相关性。WAIS-III对精神分裂症诊断的预测正确率为70.4%，而健康对照组为56.7%，孤独症组为22.8%。(C)2014爱思唯尔有限公司版权所有。
The main goal of this study was to investigate differences and similarities in general cognitive functioning between adults with schizophrenia and autism, because this has not been systematically investigated. We used a cross-sectional design to compare adults with schizophrenia (n = 27), with autism (n = 114) and a healthy control group (n = 30). Schizophrenia diagnoses were based on the Structured Clinical Interview for the DSM-IV Axis I (SCID-I) and behavioral symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Autism was diagnosed with a DSM-IV questionnaire for autism spectrum disorders and the Autistic Diagnostic Interview, revised version. The Wechsler Adult Intelligence Scale, third version (WAIS-III) was used to assess cognitive functions. All participants were between 18 and 65 years of age and had a minimum full scale intelligence of 80. Results showed that patients with schizophrenia scored significantly lower on processing speed than patients with autism and the healthy control group. Differences on other index scales were not found. In participants with schizophrenia a correlation was found between processing speed impairment and negative symptoms. Diagnosis could be predicted correctly with WAIS-III profile in 70.4% of the cases with schizophrenia compared to 56.7% of the healthy control group and 22.8% of the autism group. (C) 2014 Elsevier Ltd. All rights reserved.