CERVICOVAGINAL OVERPRODUCTION OF SPECIFIC IGG TO HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) CONTRASTS WITH NORMAL OR IMPAIRED IGA LOCAL RESPONSE IN HIV-INFECTION
CERVICOVAGINAL OVERPRODUCTION OF SPECIFIC IGG TO HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) CONTRASTS WITH NORMAL OR IMPAIRED IGA LOCAL RESPONSE IN HIV-INFECTION
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DOI：
10.1093/infdis/172.3.691
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发表时间：
1995-09-01
影响因子：
6.4
通讯作者：
PILLOT, J
中科院分区：
文献类型：
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作者：
BELEC, L;DUPRE, T;PILLOT, J
对30名感染1型人类免疫缺陷病毒（艾滋病发病前）的女性的配对血清和宫颈阴道分泌物（CVS）进行了分析，检测其中针对HIV的IgG和IgA抗体以及IgG、IgA和人血清白蛋白。将这些受试者与30名年龄匹配的健康对照者进行比较。在感染HIV的女性中，宫颈阴道免疫球蛋白显著增加，且以IgG为主。由于宫颈阴道白蛋白水平比正常对照高2.3倍，这意味着免疫球蛋白渗出增加。此外，相对于白蛋白，IgG的排泄增加了1.9倍，而IgA的分泌则趋于减少，这表明局部IgG合成可能增强。血清中IgG和IgA抗HIV抗体的平均滴度分别比CVS中高30倍和12倍，但它们在CVS中的平均比活性比血清中高，这表明两种同种型都有局部合成。与强烈的IgG反应相比，针对HIV的IgA抗体反应仍然较弱。
Paired sera and cervicovaginal secretions (CVS) from 30 women infected with human immunodeficiency virus (HIV) type 1 (before AIDS) were analyzed for IgG and IgA antibodies to HIV and for IgG, IgA, and human serum albumin. Subjects were compared with 30 age-matched healthy controls. In HIV-infected women, cervicovaginal immunoglobulins were markedly increased, and IgG predominated. An increased immunoglobulin transudation was implicated, since cervicovaginal albumin levels were 2.3-fold above those of normal controls. Furthermore, IgG excretion by reference to albumin was increased 1.9-fold, whereas the IgA secretion tended to decrease, suggesting a possible enhanced local IgG synthesis. Mean IgG and IgA anti-HIV antibody titers were, respectively, 30- and 12-fold higher in serum than in CVS, but their mean specific activities were higher in CVS than in serum, suggesting a local synthesis of both isotypes. The IgA antibody response to HIV remained poor compared with the strong Ige response.