How rhythms of the sleeping brain tune memory and synaptic plasticity.
How rhythms of the sleeping brain tune memory and synaptic plasticity.
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DOI：
10.1093/sleep/zsz095
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发表时间：
2019-04
期刊：
影响因子：
5.6
通讯作者：
Carlos Puentes-Mestril;J. Roach;Niels Niethard;M. Zochowski;S. Aton
中科院分区：
文献类型：
--
作者：
Carlos Puentes-Mestril;J. Roach;Niels Niethard;M. Zochowski;S. Aton
几十年的神经行为研究已经将不同大脑区域的睡眠相关节律与认知表现的改善联系起来。然而，目前尚不清楚哪些突触变化可能是睡眠依赖性陈述性记忆巩固和程序性任务改善的基础，以及为什么这些相同的变化似乎不会在类似的清醒时间间隔内发生。在这里，我们描述了最近的研究如何睡眠的一个特定特征网络节奏的特点，快速眼动和非快速眼动可以驱动突触加强或削弱特定的大脑回路。我们提供了一个概述，这些节奏如何影响突触可塑性个别和音乐会。我们还提出了一个总体假设，即所有发生在睡眠大脑中的网络节律如何有助于在神经回路中编码新信息。
Decades of neurobehavioral research has linked sleep-associated rhythms in various brain areas to improvements in cognitive performance. However, it remains unclear what synaptic changes might underlie sleep-dependent declarative memory consolidation and procedural task improvement, and why these same changes appear not to occur across a similar interval of wake. Here we describe recent research on how one specific feature of sleep-network rhythms characteristic of rapid eye movement and non-rapid eye movement-could drive synaptic strengthening or weakening in specific brain circuits. We provide an overview of how these rhythms could affect synaptic plasticity individually and in concert. We also present an overarching hypothesis for how all network rhythms occurring across the sleeping brain could aid in encoding new information in neural circuits.