IL-27 Negatively Controls Antifungal Activity in a Model of Invasive Pulmonary Aspergillosis
IL-27 Negatively Controls Antifungal Activity in a Model of Invasive Pulmonary Aspergillosis
复制标题
IL-27 在侵袭性肺曲霉病模型中负向控制抗真菌活性
DOI：
10.1165/rcmb.2019-0391oc
复制
发表时间：
2020-06-01
影响因子：
6.4
通讯作者：
Cao, Ju
中科院分区：
文献类型：
--
作者：
Liu, Shuang;Chen, Dapeng;Cao, Ju
Invasive pulmonary aspergillosis is a life-threatening disease, particularly in immunocompromised patients, despite currently available therapy. IL-27 is an important regulatory cytokine in infection and immunity. However, its role in the pathogenesis of invasive pulmonary aspergillosis remains unknown. Here we found that Aspergillus fumigatus pulmonary infection induced an elevated production of IL-27 in the lung. As compared with wild-type (WT) mice, IL-27R (IL-27 receptor)-deficient mice developed less severe infection when challenged with A. fumigatus conidia, as evidenced by the decreased fungal colonization and pathology of lungs and the increased survival. IL-27R deficiency led to significantly higher production of IFN-gamma in the lung after A. fumigatus infection, and the increased resistance to invasive pulmonary A. fumigatus infection in IL-27R-deficient mice was ablated by neutralizing IFN-gamma. Importantly, neutralization of IL-27 could protect WT mice against invasive pulmonary A. fumigatus infection. Our data therefore suggest an important role of IL-27 in impairing anti-A. fumigatus host immunity, which may have translational implications in treating clinical cases of invasive pulmonary aspergillosis.
