Children's 5-HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger.
Children's 5-HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger.
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DOI：
10.1080/02699931.2010.508267
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发表时间：
2011-09
影响因子：
2.6
通讯作者：
McGeary JE
中科院分区：
文献类型：
--
作者：
Gibb BE;Johnson AL;Benas JS;Uhrlass DJ;Knopik VS;McGeary JE
理论家提出，童年时期的负面经历可能有助于发展特定于经验的信息加工偏差，包括注意力偏差。对认知过程也有明显的遗传影响，有证据表明，特定候选基因的多态可能会缓和环境应激对注意偏差的影响(例如，5-羟色胺转运体基因[5-HTTLPR]的功能多态)。在本研究中，我们检验了注意偏差风险的基因×环境(G×E)模型。我们假设，母亲表现出高水平表达情绪批评(EE-Crit)的孩子会对愤怒的面孔表现出特别的注意偏向，但不会对快乐或悲伤的面孔表现出注意偏见，而且这种联系在携带一到两个5-HTTLPR短等位基因副本的儿童中会比那些携带长等位基因纯合子的儿童更强。结果大体上支持这些假设，尽管我们发现，母亲挑剔的5-HTTLPR短等位基因携带者表现出对愤怒面孔的注意回避，而不是优先注意。
Theorists have proposed that negative experiences in childhood may contribute to the development of experience-specific information-processing biases, including attentional biases. There are also clear genetic influences on cognitive processes, with evidence that polymorphisms in specific candidate genes may moderate the impact of environmental stress on attentional biases (e.g., a functional polymorphism in the serotonin transporter gene [5-HTTLPR]). In the current study, we tested a gene × environment (G × E) model of risk for attentional biases. We hypothesized that children whose mothers exhibit high levels of expressed emotion criticism (EE-Crit) would display attentional biases specifically for angry, but not happy or sad, faces, and that this link would be stronger among children carrying one or two copies of the 5-HTTLPR short allele than among those homozygous for the long allele. Results generally supported these hypotheses, though we found that carriers of the 5-HTTLPR short allele who also had a critical mother exhibited attentional avoidance of angry faces rather than preferential attention.