Experimental protocol for clinical analysis of cerebrospinal fluid by high resolution proton magnetic resonance spectroscopy
Experimental protocol for clinical analysis of cerebrospinal fluid by high resolution proton magnetic resonance spectroscopy
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DOI：
10.1016/s1385-299x(98)00033-6
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Cozzone, PJ
中科院分区：
文献类型：
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作者：
Maillet, S;Vion-Dury, J;Cozzone, PJ
脑脊液 (CSF) 高分辨率磁共振波谱 (MRS) 是一种无损分析方法，可以快速、同时检测参与中间和氧化代谢途径的分子。我们开发了一种适合冻干脑脊液样本常规 MRS 分析的方案。该程序保证了从脑脊液采集到频谱采集的样本完整性。血清 MRS 分析包含在我们的方案中，作为脑脊液分析的补充方法。该协议有助于建立脑脊液 MRS 作为一种新的分析工具，以更好地了解神经系统疾病涉及的代谢过程。 (C) 1998 Elsevier Science B.V. 保留所有权利。
High resolution magnetic resonance spectroscopy (MRS) of cerebrospinal fluid (CSF) is a non-destructive analytical method which allows rapid and simultaneous detection of molecules involved in intermediary and oxidative metabolic pathways. We developed a protocol suitable for routine MRS analysis of lyophilized CSF samples. This procedure guarantees sample integrity, from CSF collection to spectrum acquisition. MRS analysis of blood serum was included in our protocol as a complementary method to CSF analysis. This protocol can contribute to establish MRS of CSF as a new analytical tool to better understand the metabolic processes involved in neurological diseases. (C) 1998 Elsevier Science B.V. All rights reserved.