Abnormal brain processing of cutaneous pain in migraine patients during the attack
Abnormal brain processing of cutaneous pain in migraine patients during the attack
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DOI：
10.1016/s0304-3940(02)00967-9
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发表时间：
2002-11-15
影响因子：
2.5
通讯作者：
Puca, F
中科院分区：
文献类型：
--
作者：
de Tommaso, M;Guido, M;Puca, F
我们研究了偏头痛发作期间使用CO2激光刺激的皮肤痛阈值，并定义了诱发皮层电位特征。10例无先兆的患者在发作期间和随后至少72小时进行了研究。使用CO2激光脉冲在双手背部和左右眶上区产生疼痛刺激。在每个反应成分的最高峰处测量头皮电位的绝对波幅，并记录N2 a-P2成分的峰-峰幅度。与无头痛阶段相比，发作期间有症状和无症状侧的皮肤疼痛阈值均显著降低。N2 a-P2复合物在发作期间的振幅也比无痛侧增加。因此，皮肤痛觉过敏发生在偏头痛发作期间，并被中枢敏化现象所掩盖，可能涉及皮层。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
We examined cutaneous pain thresholds using CO2 laser stimuli during migraine attacks, and defined the evoked cortical potential characteristics. Ten patients without aura were studied during attacks and for at least 72 h subsequently. Pain stimuli were generated on the dorsum of both hands and the right and left supraorbital zones, using pulses from a CO2 laser. Absolute latencies of scalp potentials were measured at the highest peak of each response component, and the peak-to-peak amplitudes of N2a-P2 components were recorded. Cutaneous pain thresholds were significantly reduced on both the symptomatic and non-symptomatic sides during the attack, in comparison with the headache-free phase. The N2a-P2 complexes also increased in amplitude during attacks in comparison with the pain-free side. Thus, cutaneous hyperalgesia occurs during migraine attack, and is subtended by central sensitization phenomena, probably involving the cortex. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.