Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement
Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement
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DOI：
10.1016/j.neuron.2017.06.045
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发表时间：
2017-08-02
期刊：
影响因子：
16.2
通讯作者：
Deschenes, Martin
中科院分区：
文献类型：
--
作者：
Bellavance, Marie-Andree;Takatoh, Jun;Deschenes, Martin
动物使用主动触摸来优化它们触觉传感器的敏锐度。以前的实验结果和模型导致了这样的假设，即感觉输入以一种反复使用的方式来调整传感器的位置。电生理学、交叉遗传病毒标记和操纵以及经典追踪的组合使我们能够识别控制啮齿动物触须运动的二级感觉运动环。驱动固有肌肉延长触须的面运动神经元从位于三叉神经感觉复合体口部的神经元接受短潜伏期抑制输入，然后是突触兴奋。相反，收缩肌垫和间接收缩触须的运动神经元只接受进一步投射到丘脑的内侧神经元的兴奋性输入。压制这种反馈会改变退缩。观察到的最低层感应器运动回路的推拉电路提供了一种机制，用于在探索个人周围空间时快速调节触觉。
Animals employ active touch to optimize the acuity of their tactile sensors. Prior experimental results and models lead to the hypothesis that sensory inputs are used in a recurrent manner to tune the position of the sensors. A combination of electrophysiology, intersectional genetic viral labeling and manipulation, and classical tracing allowed us to identify second-order sensorimotor loops that control vibrissa movements by rodents. Facial motoneurons that drive intrinsic muscles to protract the vibrissae receive a short latency inhibitory input, followed by synaptic excitation, from neurons located in the oralis division of the trigeminal sensory complex. In contrast, motoneurons that retract the mystacial pad and indirectly retract the vibrissae receive only excitatory input from interpolaris cells that further project to the thalamus. Silencing this feedback alters retraction. The observed pull-push circuit at the lowest-level sensorimotor loop provides a mechanism for the rapid modulation of vibrissa touch during exploration of peri-personal space.