Numerical Simulation of Skin Formation: Modeling of Scale Peeling
Numerical Simulation of Skin Formation: Modeling of Scale Peeling
复制标题
皮肤形成的数值模拟：鳞片剥落的建模
DOI：
10.1088/1757-899x/886/1/012019
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
K. Nagayama
中科院分区：
文献类型：
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作者：
Shuji Oba;K. Nagayama
皮肤是由细胞分裂形成的，细胞最终成熟成角质并脱落。这个过程被称为周转。正常营业额，皮肤病很少发生。然而，营业额的干扰导致皮肤炎症和相关的影响，如规模的形成。水垢形成的机制尚未完全了解。这项研究分析了规模形成的影响，特应性皮炎使用数值模拟。通过理论上设定特应性皮炎的主要参数，即经表皮水分损失（此后称为TEWL），构建皮肤的数值模拟模型，从而允许阐明结垢形成的机制。结果，特应性皮炎的厚角质层和鳞屑被成功地建模。此外，角质层中桥粒分布的变化被证明与鳞屑的形成有关。
Skin is formed by cell division, and the cells eventually mature into corneums and drop off. This process is known as turnover. With normal turnover, skin disease rarely occurs. However, the disturbance of turnover leads to skin inflammation and associated effects such as scale formation. The mechanisms that underpin scale formation are not fully understood. This study analyses the impact of scale formation in atopic dermatitis using a numerical simulation. The numerical simulation model of the skin was constructed by theoretically setting the main parameters i.e. transepidermal water loss (henceforth TEWL) of atopic dermatitis, thereby allowing the elucidation of the mechanism of scale formation. As a result, thick corneum and scale of atopic dermatitis were successfully modeled. In addition, the variation of desmosome distribution in stratum corneum was shown to be associated with scale formation.