Interactions Between Therapeutics for Metabolic Disease, Cardiovascular Risk Factors, and Gut Microbiota.
Interactions Between Therapeutics for Metabolic Disease, Cardiovascular Risk Factors, and Gut Microbiota.
复制标题
代谢疾病治疗、心血管危险因素和肠道微生物群之间的相互作用
DOI：
10.3389/fcimb.2020.530160
复制
发表时间：
2020
影响因子：
5.7
通讯作者：
Tong XL
中科院分区：
文献类型：
--
作者：
Ding QY;Tian JX;Li M;Lian FM;Zhao LH;Wei XX;Han L;Zheng YJ;Gao ZZ;Yang HY;Fang XY;Tong XL
随着生活水平的提高，多种代谢紊乱的发病率逐年增加，尤其是高血糖、高血脂等心血管疾病的主要危险因素，持续增加。新兴的流行病学数据和临床试验表明，一些代谢治疗药物对心血管疾病有额外的保护作用。一系列研究发现，这些药物可能通过调节肠道微生物群的组成来发挥作用。在这篇综述中，我们简要概述了肠道微生物群对代谢紊乱和心血管疾病的贡献，以及肠道微生物群对具有心血管益处的代谢治疗药物的反应。通过这种方式，我们将代谢治疗药物的微生物组研究的最新进展与其心血管保护作用联系起来，表明肠道微生物可能在减少心血管危险因素方面发挥潜在作用。我们还讨论了微生物靶向治疗作为预防和/或治疗心血管疾病的治疗策略的潜力，并强调需要建立代谢疾病治疗，肠道微生物群调节和心血管保护之间的因果关系。
With improved standards of living, the incidence of multiple metabolic disorders has increased year by year, especially major risk factors for cardiovascular disease such as hyperglycemia and hyperlipidemia, continues to increase. Emerging epidemiological data and clinical trials have shown the additional protective effects of some metabolic therapy drugs against cardiovascular diseases. A series of studies have found that these drugs may work by modulating the composition of gut microbiota. In this review, we provide a brief overview of the contribution of the gut microbiota to both metabolic disorders and cardiovascular diseases, as well as the response of gut microbiota to metabolic therapy drugs with cardiovascular benefits. In this manner, we link the recent advances in microbiome studies on metabolic treatment drugs with their cardiovascular protective effects, suggesting that intestinal microorganisms may play a potential role in reducing cardiovascular risk factors. We also discuss the potential of microorganism-targeted therapeutics as treatment strategies for preventing and/or treating cardiovascular disease and highlight the need to establish causal links between therapeutics for metabolic diseases, gut microbiota modulation, and cardiovascular protection.
影响因子：
4.3
作者：
Chen JM;Chang CW;Lin YC;Horng JT;Sheu WH
通讯作者：
Sheu WH