Household transmission of SARS-CoV-2
Household transmission of SARS-CoV-2
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DOI：
10.1016/j.jinf.2020.03.040
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发表时间：
2020-07-01
影响因子：
28.2
通讯作者：
Zhang, Ruiguang
中科院分区：
文献类型：
--
作者：
Wang, Zhongliang;Ma, Wanli;Zhang, Ruiguang
背景：严重急性呼吸综合征冠状病毒2型在中国等多个国家引起疫情。在家庭中发现了许多感染聚集性病例，但关于家庭接触者二次传播的数据有限。方法：在这个回顾性病例系列中，我们纳入了武汉市85例SARS-CoV-2感染者及其家庭成员。咽拭子实时逆转录-聚合酶链式反应(RT-PCR)检测证实患者感染SARS-CoV-2。收集家庭成员流行病学、临床和实验室资料。结果：共有155名密切接触者。104名接触者进行了RT-PCR检测，其中47例(30%)为阳性，57例(37%)为阴性。51例(33%)患者在隔离2周内未出现肺炎症状，未接受RT-PCR检测。有1次接触者家庭密切接触者感染率为38%，2次接触者为50%，3次接触者为31%。结论：SARS-CoV-2感染者家庭接触者二次传播率为30%。我们的数据为SARS-CoV-2在家庭中的二次传播率提供了洞察。(C)2020年英国感染协会。爱思唯尔有限公司出版。保留所有权利。
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an epidemic in China and many other countries. Many infected clusters have been found within familial households, but the data about secondary transmission among household contacts is limited.Methods: In this retrospective case series, we enrolled 85 patients infected with SARS-CoV-2 and their household members in Wuhan. Patients were confirmed infected with SARS-CoV-2 by real-time reverse transcription polymerase chain reaction (RT-PCR) assays on throat swabs. Epidemiological, clinical and laboratory data of the household members were collected.Results: There were 155 close contacts in total. 104 contacts received RT-PCR assays, with 47 (30%) positive cases and 57 (37%) negative cases. 51 (33%) cases did not received RT-PCR tests for they showed no symptoms of pneumonia during the 2 weeks of quarantine. The infection rate of close contacts was 38% for households with 1 contact, 50% for households with 2 contacts, and 31% for households with 3 contacts.Conclusions: The rate of secondary transmission among household contacts of patients with SARS-CoV-2 infection was 30%. Our data provide insight into the rate of secondary transmission of SARS-CoV-2 in home. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.