Decreased Apoptosis following Successful Ablation of Atrial Fibrillation
Decreased Apoptosis following Successful Ablation of Atrial Fibrillation
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DOI：
10.1159/000319619
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发表时间：
2010-01-01
期刊：
影响因子：
1.9
通讯作者：
Vondrak, Karel
中科院分区：
文献类型：
--
作者：
Osmancik, Pavel;Peroutka, Zdenek;Vondrak, Karel
目的：心房颤动（AF）患者心脏组织样本中细胞凋亡过程的增加已经在动物实验中得到证实。窦性心律的恢复是否与细胞凋亡的减少有关尚不清楚。本研究的目的是确定心房颤动心外膜消融成功是否会导致血清细胞凋亡标志物浓度的变化。方法：对25例房颤患者进行前瞻性研究。所有患者均行心外膜肺静脉隔离术。消融的成功通过临床和3次动态心电图记录进行评估。术前、术后3个月和6个月分别抽取血样。采用ELISA法检测血清促凋亡片段Fas和肿瘤坏死因子相关凋亡诱导配体TRAIL的浓度。结果：15例AF消融成功（SR组）。其余10例（房颤组）在随访期间房颤复发。两组在年龄、性别、左心室射血分数或术前测量分子浓度方面均无差异。虽然成功消融患者的Fas下降，但AF组的Fas浓度没有变化。同样，SR组TRAIL浓度下降，AF组保持不变。结论：房颤消融与血清细胞凋亡标志物降低有关。版权所有：S. Karger AG，巴塞尔
Objectives: Increased apoptotic processes in tissue samples from hearts in atrial fibrillation (AF) have been previously documented in animals. Whether the restoration of sinus rhythm is associated with decreased apoptosis is not known. The aim of the present study was to establish whether successful epicardial ablation of AF leads to changes in the concentration of serum markers of apoptosis. Methods: Twenty-five patients with AF were prospectively studied. All underwent epicardial isolation of pulmonary veins. The success of the ablation was assessed clinically and with 3 Holter recordings. Blood samples were drawn before surgery, and at 3 and 6 months after. Serum concentrations of Fas (apoptosis-stimulating fragment) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) were measured using ELISA. Results: AF was successfully ablated in 15 patients (SR group). In the other 10 patients (AF group), AF recurred during follow-up. Neither group differed with respect to age, sex, left ventricular ejection fraction, or preoperative concentrations of measured molecules. While Fas decreased in successfully ablated patients, there was no change in the Fas concentration in the AF group. Similarly, the concentrations of TRAIL decreased in the SR group, but remained unchanged in the AF group. Conclusion: The ablation of AF is associated with decreased serum markers for apoptosis. Copyright (C) 2010 S. Karger AG, Basel