Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
Antitumor agents. 221.1 buceracidins A and B, two new flavanones from Bucida buceras.
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抗肿瘤剂。
DOI：
10.1021/np0203483
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Lee,Kuo-Hsiung
中科院分区：
文献类型：
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作者：
Hayashi,Ken-Ichiro;Nakanishi,Yuka;Bastow,KennethF;Cragg,Gordon;Nozaki,Hiroshi;Lee,Kuo-Hsiung
作为热带雨林植物抗肿瘤药物研究的一部分，从五味子中分离得到两个新的黄烷酮类化合物5，2‘-dihydroxy-3-methoxy-6，7-(2‘ ‘，2‘ ‘-dimethylchromene)flavanone，和B(2)，5，2‘-dihydroxy-6，7-(2‘ ‘，2‘ ‘-dimethylchromene)flavanone，和4个已知的戊二烯基黄烷酮：小花青素(3)、3-羟基小花青素(4)、3-甲氧基小花青素(5)和苦豆素(6)。通过详细的2D核磁共振波谱分析，确定了两个化合物的结构。在6种黄烷酮中，3、5和6在人类肿瘤细胞系中具有轻微的细胞毒性。
As part of a study on antitumor agents from rainforest plants, two new flavanones, buceracidin A (1), 5,2‘-dihydroxy-3-methoxy-6,7-(2‘ ‘,2‘ ‘-dimethylchromene)flavanone, and buceracidin B (2), 5,2‘-dihydroxy-6,7-(2‘ ‘,2‘ ‘-dimethylchromene)flavanone, were isolated together with four known prenylated flavanones, minimiflorin (3), 3-hydroxyminimiflorin (4), 3-methoxyminimiflorin (5), and mundulinol (6), fromBucida buceras. The structures of buceracidins A and B were elucidated from detailed 2D NMR analyses. Among the six flavanones,3,5, and6were marginally cytotoxic in a human tumor cell line panel.