A genome-wide scan of loci linked to serum adiponectin in two populations of African descent
A genome-wide scan of loci linked to serum adiponectin in two populations of African descent
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DOI：
10.1038/oby.2007.142
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发表时间：
2007-05-01
期刊：
影响因子：
6.9
通讯作者：
Cooper, Richard S.
中科院分区：
文献类型：
--
作者：
Hicks, Chindo;Zhu, Xiaofeng;Cooper, Richard S.
目的：确定与血清脂联素浓度相关的数量性状基因座，并估计两个非洲人后裔的遗传力。研究方法和程序：我们对两个非洲人后裔的血清脂联素浓度进行了基因组扫描。全基因组微卫星标记在由来自芝加哥地区的203个家庭组成的非裔美国人群体和由146个家庭组成的尼日利亚约鲁巴人群体中进行了分型。进行连锁分析以确定基因座。结果：经年龄、性别和BMI调整后，非裔美国人和尼日利亚家庭的遗传度估计值分别为0.45和0.70。在这两个人群中，脂联素与BMI、身高和体重显著负相关。在调整了年龄、性别和体重指数后，我们在尼日利亚样本中发现了与脂联素基因连锁的证据，分别位于第11和17号染色体[LOD分数=2.89]和17号染色体(LOD分数=1.35)。在非裔美国人中，我们发现2号染色体(LOD分数=1.82)、4号染色体(LOD分数=2.12)和11号染色体(LOD分数=2.33)上存在遗传连锁。基于综合数据的分析得出11号染色体上的最大LOD分数为3.21。讨论：11号染色体上发现的一致性表明，该区域可能参与了脂联素的调节，要么是通过对激素水平的初级影响，要么是通过影响身体成分的途径。这些结果表明，脂联素可能成为治疗肥胖症的潜在靶点。
Objective: The objectives were to identify quantitative trait loci linked to serum adiponectin concentration and to estimate heritability in two populations of African descent.Research Methods and Procedures: We conducted a genome scan for serum adiponectin concentration in two populations of African descent. Genome-wide microsatelitte markers were typed in an African-American population consisting of 203 families from the Chicago area and in a Nigerian Yoruba population consisting of 146 families. Linkage analysis was performed to identify loci. Variance component model was used to estimate heritability.Results: Estimates of heritability adjusted for age, gender, and BMI were 0.45 and 0.70 for the African-American and Nigerian families, respectively. In both populations, adiponectin was significantly negatively correlated with BMI, height, and weight. After adjusting for age, gender, and BMI, we found evidence of genetic linkage to adiponectin on chromosomes 11 [limit of detection (LOD) score = 2.89] and 17 (LOD score = 1.35) in the Nigerian sample. Among the African-Americans, we found genetic linkage on chromosomes 2 (LOD score = 1.82), 4 (LOD score = 2.12), and 11 (LOD score = 2.33). Analysis based on combined data yielded a maximum LOD score of 3.21 on chromosome 11.Discussion: Consistency of the finding on chromosome 11 suggests that this region is likely to be involved in regulation of adiponectin, either through a primary influence on hormone levels or through pathways influencing body composition. These results suggest that adiponectin could be a potential therapeutic target for obesity.