Comparison of acute low-tone sensorineural hearing loss versus Meniere's disease by electrocochleography
Comparison of acute low-tone sensorineural hearing loss versus Meniere's disease by electrocochleography
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DOI：
10.1177/000348940411300304
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发表时间：
2004-03-01
影响因子：
1.4
通讯作者：
Kitamura, K
中科院分区：
文献类型：
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作者：
Noguchi, Y;Nishida, H;Kitamura, K
为探讨急性低音调感音神经性聋(ALHL)的发病机制，我们对20例ALHL患者和58例美尼埃病(MD)患者按纯音平均分为4组(MD1~MD4)进行了回顾性比较。ALHL组的平均总和电位-动作电位比率为0.35+/-0.13，显著高于对照组，但与MDI组的比率(纯音平均听力水平和25分贝听力)相近。ALHL组的耳蜗微音素平均检测阈值为32.0+/-9.4分贝正常听力水平，与MD I组相近。此外，50%以上的ALHL患者的耳蜗微音学输入-输出曲线正常。因此，我们得出结论，ALHL的发病机制是由内淋巴积水引起的，毛细胞损伤很少或没有，类似于早期MD。
To clarify the pathogenesis of acute low-tone sensorineural hearing loss (ALHL), we retrospectively compared the electrocochleo-graphic findings from 20 patients with ALHL with those from 58 patients with Meniere's disease (MD) classified into 4 groups (MD I through MD4) according to their pure tone average. The mean summating potential-action potential ratio in the ALHL group was 0.35 +/- 0.13, which was significantly higher than the control ratio but similar to the ratio seen in the MDI group (pure tone average < 25 dB hearing level). The mean detection threshold of the cochlear microphonics in the ALHL group was 32.0 +/- 9.4 dB normal hearing level, which was again similar to that seen in the MD I group. Moreover, more than 50% of patients with ALHL had normal cochlear microphonics input-output curves. We therefore conclude that the pathogenesis of ALHL arises from an endolymphatic hydrops with little or no impairment of hair cells that resembles early-stage MD.