Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice
Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice
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DOI：
10.1016/j.pnpbp.2010.06.024
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发表时间：
2010-10
影响因子：
5.6
通讯作者：
Li-Tao Yi;Cheng-fu Li;X. Zhan;C. Cui;Fei Xiao;Li-Pan Zhou;Yong Xie
中科院分区：
文献类型：
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作者：
Li-Tao Yi;Cheng-fu Li;X. Zhan;C. Cui;Fei Xiao;Li-Pan Zhou;Yong Xie
膳食黄酮类化合物在包括抑郁症在内的各种中枢神经病理生理状况中具有多种神经保护作用。在这项研究中，在抑郁症小鼠行为模型中研究了膳食类黄酮柚皮素的神经药理学机制。为此，我们研究了分别用血清素或去甲肾上腺素合成抑制剂、对氯苯丙氨酸甲酯或α-甲基-对酪氨酸进行预处理对柚皮素抗不动作用的影响。与对照组相比，柚皮素在小鼠悬尾试验（10、20和50mg/kg）中显着减少了急性治疗后的不动时间，但在强迫游泳试验中没有，在旷场试验中没有产生运动改变。此外，在悬尾试验中，用对氯苯丙氨酸甲酯（100mg/kg）或α-甲基-对酪氨酸（100mg/kg）预处理小鼠可阻止柚皮素（20mg/kg）的抗不动作用。总而言之，这些数据表明柚皮素通过中枢血清素能和去甲肾上腺素能系统具有有效的抗抑郁样特性。因此，我们的研究结果表明，这种膳食黄酮类化合物在中枢神经系统疾病，特别是涉及单胺能系统的抑郁症中具有治疗潜力。
Dietary flavonoids possess a multiplicity of neuroprotective actions in various central nervous pathophysiological conditions including depression. In this study, the neuropharmacological mechanism of the dietary flavonoid naringenin was investigated in the mouse behavioral models of depression. For this purpose, we investigated the influence of pretreatment with the inhibitors of serotonin or noradrenaline synthesis, p-chlorophenylalanine methyl ester or α-methyl-p-tyrosine, respectively in the anti-immobility effect of naringenin. Compared to the control group, naringenin significantly decreased the immobility time after acute treatment in the mouse tail suspension test (10, 20 and 50mg/kg), but not in the forced swimming test, without producing locomotor alteration in the open-field test. In addition, pretreatment of mice with p-chlorophenylalanine methyl ester (100mg/kg) or α-methyl-p-tyrosine (100mg/kg) prevented the anti-immobility effect of naringenin (20mg/kg) in the tail suspension test. Taken together, this data demonstrated that naringenin possessed potent antidepressant-like property via the central serotonergic and noradrenergic systems. Thus, our findings suggest the therapeutic potential of this dietary flavonoid in central nervous system disorders especially depression where monoaminergic systems are involved.