Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells.
Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells.
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BLV 感染细胞中牛白血病病毒长末端重复序列的反式激活。
DOI：
10.1126/science.2981432
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Haseltine,WA
中科院分区：
文献类型：
--
作者：
Rosen,CA;Sodroski,JG;Kettman,R;Burny,A;Haseltine,WA
逆转录病毒的转录起始信号位于整合原病毒侧面的长末端重复序列（LTR）中。本研究表明，感染牛白血病病毒（BLV）的细胞中存在的因子介导了BLV LTR的转录反式激活，这一现象与报道的人t细胞白血病病毒LTR相似，并建立了BLV和人t细胞白血病病毒在同一转化逆转录病毒家族中的结构和功能标准。
The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. This study shows that factors present in cells infected with bovine leukemia virus (BLV) mediate transcriptional trans activation of the BLV LTR. This phenomenon is similar to that reported for the human T-cell leukemia virus LTR and establishes both structural and functional criteria for inclusion of BLV and human T-cell leukemia viruses in the same family of transforming retroviruses.