Parvovirus replication.
Parvovirus replication.
复制标题
细小病毒复制。
DOI：
10.1128/mr.54.3.316-329.1990
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Berns,KI
中科院分区：
文献类型：
--
作者：
Berns,KI
细小病毒科的成员是DNA病毒中最小的，具有约5个内切酶的线性单链基因组。目前，该科分为三个属，其中两个属包含脊椎动物病毒，第三个属包含昆虫病毒。这篇综述集中在脊椎动物病毒，重点是我们对病毒复制的分子生物学的最新进展。传统上，脊椎动物病毒通过在生产性感染发生之前是否需要与辅助病毒共感染来区分，因此认为依赖病毒（腺相关病毒[AAV]）是有缺陷的。最近的数据表明，这两种脊椎动物病毒不仅在结构和遗传组织上有很大的相似性，而且在生产性复制的分子生物学上也有显著的相似性。不同之处在于宿主细胞的生理条件使其变得允许。健康的分裂细胞允许自主细小病毒的生产性复制;这些细胞导致依赖病毒的潜伏感染。为了使细胞变得允许生产性AAV复制，它必须暴露于激活潜伏AAV基因组的毒性条件。这种情况可能是由辅助病毒感染或暴露于物理（紫外线）或化学（某些致癌物质）剂引起的。本文综述了复制的分子生物学，特别强调了宿主的作用和病毒感染对宿主的影响。
The members of the family Parvoviridae are among the smallest of the DNA viruses, with a linear single-stranded genome of about 5 kilobases. Currently the family is divided into three genera, two of which contain viruses of vertebrates and a third containing insect viruses. This review concentrates on the vertebrate viruses, with emphasis on recent advances in our insights into the molecular biology of viral replication. Traditionally the vertebrate viruses have been distinguished by the presence or absence of a requirement for a coinfection with a helper virus before productive infection can occur, hence the notion that the dependoviruses (adeno-associated viruses [AAV]) are defective. Recent data would suggest that not only is there a great deal of structural and genetic organizational similarity between the two types of vertebrate viruses, but also there is significant similarity in the molecular biology of productive replication. What differs is the physiological condition of the host cell that renders it permissive. Healthy dividing cells are permissive for productive replication by autonomous parvoviruses; such cells result in latent infection by dependoviruses. For a cell to become permissive for productive AAV replication, it must have been exposed to toxic conditions which activate a latent AAV genome. Such conditions can be caused by helper-virus infection or exposure to physical (UV light) or chemical (some carcinogens) agents. In this paper the molecular biology of replication is reviewed, with special emphasis on the role of the host and the consequences of viral infection for the host.