[Role of novel mitochondrial proteins in energy balance].
[Role of novel mitochondrial proteins in energy balance].
复制标题
[新型线粒体蛋白在能量平衡中的作用]。
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Palacín
中科院分区：
文献类型：
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作者：
A. Zorzano;D. Bach;S. Pich;M. Palacín
线粒体活性在恒温生物体的产热和能量消耗中起着关键作用。近年来，作为非偶联呼吸调节因子的UCP家族新成员受到了人们的广泛关注。然而，线粒体生物学的其他方面可能对理解线粒体功能也是至关重要的，这些方面尚未被认识到。因此，由于融合和裂变事件的操作，线粒体在许多细胞类型中以细丝或网络的形式组织。参与线粒体融合的丝裂原蛋白-2能刺激线粒体底物氧化、细胞呼吸和线粒体膜电位，提示该蛋白可能在线粒体代谢中发挥重要作用，从而影响能量平衡。此外，观察到肥胖骨骼肌中丝裂原蛋白-2的表达被抑制，这表明在肥胖的病理生理学和/或发病机制中可能起到了作用。
Mitochondrial activity plays a key role in the control of thermogenesis and energy expenditure in homeothermic organisms. Recently, much attention has been paid to the novel protein members of UCP family as putative regulators of uncoupled respiration. Nevertheless, it is likely that other aspects, as yet unrecognized, of mitochondrial biology are also crucial to comprehend mitochondrial function. Thus, mitochondria are organized in filaments or in networks in many cell types as a result of the operation of fusion and fission events. The demonstration that mitofusin-2, a protein involved in mitochondrial fusion, stimulates the mitochondrial oxidation of substrates, cell respiration and mitochondrial membrane potential suggests that this protein may play an important role in mitochondrial metabolism, and as a consequence, in energy balance. Furthermore, the observation that mitofusin-2 expression is repressed in obese skeletal muscle suggests a posible role in the pathophysiology and/or etiopathogenesis of obesity.