Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells
Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells
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Decalpenic Acid 是一种来自疣状青霉 CR37010 的新型小分子，可诱导多能间充质细胞中的早期成骨细胞标志物
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Y. Akamatsu
中科院分区：
文献类型：
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作者：
Shuichi Sakamoto;F. Kojima;M. Igarashi;R. Sawa;M. Umekita;Y. Kubota;Koichi Nakae;Sho;H. Adachi;Y. Nishimura;Y. Akamatsu
成骨细胞是在胚胎发育和成年期负责骨形成的细胞。能够诱导成骨细胞分化的小分子化合物可能是治疗骨质疏松症等骨疾病的有希望的来源。在筛选小鼠多能间充质C3 H10 T1/2细胞成骨细胞分化诱导剂的过程中，我们从疣状青霉CR 37010的发酵液中分离出一种小分子化合物。这种化合物，命名为十碳烯酸，带有一个十氢化萘部分与四烯酸侧链。在我们的实验条件下，单独用癸烯酸处理C3 H10 T1/2细胞诱导早期成骨细胞标志物的表达，如碱性磷酸酶活性和骨桥蛋白mRNA，但不诱导晚期成骨细胞标志物骨钙素mRNA或脂肪细胞标志物。
Osteoblasts are the cells responsible for bone formation during embryonic development and adult life. Small compounds that could induce osteoblast differentiation might be promising sources of therapies for bone diseases such as osteoporosis. During screening for inducers of osteoblast differentiation of mouse pluripotent mesenchymal C3H10T1/2 cells, we isolated a small compound from the fermentation broth of Penicillium verruculosum CR37010. This compound, named decalpenic acid, bears a decalin moiety with a tetraenoic acid side chain. Treatment of C3H10T1/2 cells with decalpenic acid alone induced the expression of early osteoblast markers, such as alkaline phosphatase activity and osteopontin mRNA, but did not induce the late osteoblast marker osteocalcin mRNA or adipocyte markers under our experimental conditions.
影响因子：
3.3
作者：
Hata, K;Nishimura, R;Yoneda, T
通讯作者：
Yoneda, T