Joint Effects of Genetic Variants in Multiple Loci on the Risk of Coronary Artery Disease in Chinese Han Subjects
Joint Effects of Genetic Variants in Multiple Loci on the Risk of Coronary Artery Disease in Chinese Han Subjects
复制标题
多位点遗传变异对中国汉族受试者冠状动脉疾病风险的联合影响
DOI：
10.1253/circj.cj-12-0156
复制
发表时间：
2012-08-01
影响因子：
3.3
通讯作者：
Ling, Wenhua
中科院分区：
文献类型：
--
作者：
Lv, Xiaofei;Zhang, Yuan;Ling, Wenhua
背景资料：本研究的目的是探讨冠心病（CAD）的风险变量，并评估其联合效应（量化的遗传风险评分; GRS）对中国汉族sample.Methods和结果：91个单核苷酸多态性（SNPs）与CAD风险的关联分析进行了1,007例CAD患者和889名健康对照。两个GRS，计数GAS（cGRS）和加权GRS（wGRS），计算使用显着的SNPs，并使用受试者工作特征（ROC）曲线分析评估其对CAD的判别力。8个SNPs（rs 11206510、rs 10118757、rs 2383206、rs 501120、rs 2075292、rs 174547、rs 173539和rs 255052）与CAD名义上显著相关（P
Background: The aim of the present study was to explore risk variants for coronary artery disease (CAD) and to evaluate their joint effects (quantified by genetic risk score; GRS) on the discrimination of CAD in a Chinese Han sample.Methods and Results: An association analysis of 91 single nucleotide polymorphisms (SNPs) with CAD risk was undertaken in 1,007 CAD patients and 889 healthy controls. Two GRSs, counted GAS (cGRS) and weighted GRS (wGRS), were calculated using the significant SNPs, and their discriminant power for CAD was assessed using receiver-operating characteristic (ROC) curve analysis. Eight SNPs (rs11206510, rs10118757, rs2383206, rs501120, rs2075292, rs174547, rs173539, and rs255052) were nominally significantly associated with CAD (P