Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles
Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles
复制标题
水介质中钯催化的串联加成/环化：2-芳基吲哚的合成
DOI：
10.1039/c7ob00572e
复制
发表时间：
2017
影响因子：
3.2
通讯作者：
Jiuxi Chen
中科院分区：
文献类型：
--
作者：
Shuling Yu;Kun Hu;Julin Gong;Linjun Qi;Jianghe Zhu;Yetong Zhang;Tianxing Cheng;Jiuxi Chen
An efficient protocol to construct 2-arylindoles was developed through palladium-catalyzed tandem addition/cyclization of potassium aryltrifluoroborates with aliphatic nitriles in aqueous medium. The use of water as the reaction medium makes the synthesis process environmentally benign. A plausible mechanism for the formation of 2-arylindoles involving sequential nucleophilic addition followed by an intramolecular cyclization is proposed. Moreover, the utility of this catalytic tandem transformation was also demonstrated in an efficient gram-scale synthesis. This method provides an alternative synthetic tool for accessing a more diverse array of 2-arylindoles.
