The TonB energy transduction systems in Vibrio species.
The TonB energy transduction systems in Vibrio species.
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DOI：
10.2217/fmb.10.90
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发表时间：
2010-09
影响因子：
3.1
通讯作者：
Crosa JH
中科院分区：
文献类型：
--
作者：
Kuehl CJ;Crosa JH
通过研究弧菌属中TonB系统的组织和保护，我们可以梳理出基因排列和功能的趋势，从而为多个TonB系统中蛋白质的进化和必要性提供线索。TonB2系统，与额外的TtpC蛋白，一般更混杂的关于他们的相互作用与许多不同的TonB依赖性转运蛋白在外膜。研究表明，TtpC蛋白跨越周质空间，这表明它可能是质子动力和外膜蛋白受体之间的能量连接，而较短的TonB2不能提供。作为一个早期的系统，TtpC蛋白和TonB2系统的组合对于较小的TonB2蛋白的功能和在可能具有渗透挑战的介质中吸收能量必须是必需的。
Studying the organization and conservation of the TonB systems across the genus Vibrio, we can tease out trends in gene arrangement and function that lead to clues about the evolution and necessity of the proteins in multiple TonB systems. The TonB2 systems, with additional TtpC proteins, are in general more promiscuous regarding their interactions with many different TonB-dependent transporters in the outer membrane. Studies show that the TtpC protein spans the periplasmic space, suggesting that it can be the connection between the energy from the proton motive force and the outer membrane protein receptors, which the shorter TonB2 cannot provide. As an earlier system, the combination of the TtpC protein and a TonB2 system must have been necessary for the function of the smaller TonB2 protein and to transduce energy in a medium that can have osmotic challenges.