Impact of early and standardized treatment with amiodarone on therapeutic success and outcome in pediatric patients with postoperative tachyarrhythmia
Impact of early and standardized treatment with amiodarone on therapeutic success and outcome in pediatric patients with postoperative tachyarrhythmia
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DOI：
10.1016/j.jtcvs.2008.04.011
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发表时间：
2008-11-01
影响因子：
6
通讯作者：
Camphausen, Christoph K.
中科院分区：
文献类型：
--
作者：
Haas, Nikolaus A.;Camphausen, Christoph K.
目标：先天性心脏病矫正手术后开始胺碘酮抗心律失常治疗时机的影响尚未明确。方法：在一项为期10年的前瞻性观察研究中，2651例患者中有71例（2885例手术，2106例旁路手术）接受胺碘酮治疗新检测到的术后房性（n = 70）或室性（n = 7）快速性心律失常：早期治疗（在心律失常检测后60分钟内开始）和晚期治疗（之后）。根据中期分析，建立了治疗方案（32例患者）。结果：早期治疗组（n = 29），胺碘酮开始前延迟时间为40.7 ± 21.9分钟，而对照组为227.7 ± 228.1分钟（P
Objective: Effects of timing of inception of amiodarone antiarrhythmic treatment after corrective surgery for congenital heart defects are not yet well defined.Methods: In a 10-year prospective observational study, 71 of 2651 patients (2885 procedures, 2106 bypass procedures) received amiodarone for newly detected postoperative atrial (n = 70) or ventricular (n = 7) tachyarrhythmia: early treatment (initiation within 60 minutes of arrhythmia detection) and late treatment (after that). From an interim analysis, a treatment protocol was established (32 patients). Inotropic requirements were monitored, as were heart rate, blood pressure, central venous pressure, and sedation requirements.Results: With early treatment (n = 29), delay before start of amiodarone was 40.7 +/- 21.9 minutes, versus 227.7 +/- 228.1 minutes (P