Lung asbestos content in chrysotile workers with mesothelioma.
Lung asbestos content in chrysotile workers with mesothelioma.
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患有间皮瘤的温石棉工人的肺石棉含量。
DOI：
10.1164/arrd.1984.130.6.1042
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
B. Stevens
中科院分区：
文献类型：
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作者：
A. Churg;B. Wiggs;L. Depaoli;B. Kampe;B. Stevens
温石棉在人类间皮瘤发生中的作用是有争议的。我们分析了肺石棉含量在6个长期温石棉矿工和米莱尔主胸膜间皮瘤。在5名患者中，只发现了温石棉矿石成分（温石棉和透闪石/阳起石/直闪石类角闪石石棉），而第6名患者既有温石棉矿石成分，也有铁石棉，铁石棉是一种并非来自采矿过程的石棉。仅含有温石棉矿成分的5名间皮瘤患者的平均纤维数/克干肺较高（温石棉64 X 10（6）和透闪石组540 X 10（6）比一组长期温石棉矿工对照受试者（温石棉23 × 10（6），透闪石组58 × 10（6），但一些间皮瘤患者的纤维负荷接近对照范围的平均值。间皮瘤组的纤维大小和纵横比与对照组的纤维大小和纵横比大致相同，并且纤维分布分析未能显示在肺外周的任何优先定位。然而，间皮瘤病例与对照病例相比，肺中透闪石的浓度比为9.3，而温石棉的浓度比仅为2.8。我们的研究结果提供了强有力的证据表明，温石棉矿粉尘（温石棉和闪石成分）可以产生间皮瘤在人类中，更大的相对量的透闪石组闪石存在于间皮瘤患者提出的可能性，这些纤维可能是重要的肿瘤的发病机制。
The role of chrysotile asbestos in the genesis of mesotheliomas in humans is disputed. We analyzed the asbestos content of the lung in 6 long-term chrysotile miners and millers who had pleural mesotheliomas. In five patients, only chrysotile ore components (chrysotile and tremolite/actinolite/anthophyllite types of amphibole asbestos) were found, while the sixth patient presented both chrysotile ore components and amosite, a type of asbestos that is not derived from the mining process. The mean number of fibers/g dry lung for the 5 patients with mesothelioma containing only chrysotile ore components was higher (chrysotile 64 X 10(6) and tremolite group 540 X 10(6] than in a group of long-term chrysotile miner control subjects who had no asbestos-related disease (chrysotile 23 X 10(6), tremolite group 58 X 10(6], but some patients with mesothelioma had fiber burdens near the mean of the control range. Fiber sizes and aspect ratios in the mesothelioma group were approximately the same as those in the control subjects, and analysis of fiber distribution failed to show any preferential localization in the periphery of the lung. However, the concentration ratio of tremolite in the lungs of the mesothelioma cases compared to the control cases was 9.3, while the ratio of chrysotile was only 2.8. Our findings provide strong evidence that chrysotile mine dust (chrysotile and amphibole components) can produce mesotheliomas in humans; the greater relative amounts of tremolite group amphiboles present in the patients with mesothelioma raise the possibility that these fibers may be important in the pathogenesis of the tumors.