The Effect of Parathyroid Extract on the Serum Concentrations of Calcium and Inorganic Phosphate in Active and Healing Rickets
The Effect of Parathyroid Extract on the Serum Concentrations of Calcium and Inorganic Phosphate in Active and Healing Rickets
复制标题
甲状旁腺提取物对活动性和愈合性佝偻病血清钙和无机磷酸浓度的影响
DOI：
10.1111/j.1651-2227.1964.tb07216.x
复制
发表时间：
1964
期刊：
影响因子：
--
通讯作者：
R. Steendijk
中科院分区：
文献类型：
--
作者：
R. Steendijk
几年前，Harrison，Harrison & Park [3，51]表明，对低钙血症维生素D缺乏大鼠给予甲状旁腺提取物对钙和无机磷酸盐（血清-Ca和血清P）的血清浓度没有影响。当甲状旁腺提取物注射48小时后，维生素D，血清钙上升，血清P下降。Jonxis [6]在儿童中报告了类似的发现。在正常儿童甲状旁腺提取物引起的血清钙和血清P下降，而在维生素D缺乏的孩子，这些浓度不受甲状旁腺提取物。这些研究得出的结论是，维生素D对甲状旁腺激素的作用具有许可作用。本研究的目的是观察维生素D治疗严重维生素D缺乏性佝偻病时甲状旁腺提取物对血清钙和血清磷的影响，以确定甲状旁腺提取物在治疗过程的哪个阶段可以引起正常反应。
Some years ago, Harrison, Harrison & Park [3, 51 showed that administration of parathyroid extract to hypocalcaemic vitamin D-deficient rats had no effect on the serum concentrations of calcium and inorganic phosphate (serum-Ca and serumP). When parathyroid extract was injected 48 hours after administration of vitamin D, serum-Ca rose and serum-P fell. Jonxis [6] reported similar findings in children. In the normal child paratllyroid extract caused a rise of serum-Ca and a fall of serum-P, whereas in the vitamin Ddeficient child these concentrations were unaffected by parathyroid extract. These studies led to the conclusion that vitamin D has a permissive action on the effects of parathyroid hormone. The purpose of the study presented here was to follow the effect of parathyroid extract on serum-Ca and serum-P during the healing of severe vitamin D-deficient rickets with vitamin D in order t o find out a t which stage of the healing process a normal response to parathyroid extract could be elicited.